Marois P, Di Franco E, Boulay G, Flipot P, Assaf R, Lamoureux G
Institut Armand-Frappier, Ville de Laval, Québec.
Can J Vet Res. 1989 Oct;53(4):394-9.
This study was designed to determine in six-week old specific pathogen free pigs, the effect of previous experimental exposure to Mycoplasma hyopneumoniae and transmissible gastroenteritis virus on a challenge infection with Actinobacillus pleuropneumoniae. Pigs exposed simultaneously to M. hyopneumoniae and transmissible gastroenteritis virus appeared more resistant to challenge (one week later) with A. pleuropneumoniae. Four pigs out of a group of ten died following the challenge infection, compared to all ten pigs in the control group not submitted to previous infections. Clinical signs and lesions were also less severe in the previously infected group than in the control group. Pigs submitted to a single previous infection with M. hyopneumoniae only appeared to be less resistant to the challenge infection than pigs submitted to the dual previous infection with M. hyopneumoniae and the transmissible gastroenteritis virus. A correlation was found between the resistance of pigs to the challenge infection and their serum gammaglobulin levels.
本研究旨在确定在6周龄的无特定病原体猪中，先前实验性暴露于猪肺炎支原体和传染性胃肠炎病毒对感染胸膜肺炎放线杆菌的影响。同时暴露于猪肺炎支原体和传染性胃肠炎病毒的猪，似乎对（一周后）胸膜肺炎放线杆菌的攻击感染更具抵抗力。在一组10头猪中，有4头在攻击感染后死亡，而未接受先前感染的对照组10头猪全部死亡。先前感染组的临床症状和病变也比对照组轻。仅先前感染过猪肺炎支原体的猪，似乎比先前同时感染猪肺炎支原体和传染性胃肠炎病毒的猪对攻击感染的抵抗力更弱。研究发现猪对攻击感染的抵抗力与其血清γ球蛋白水平之间存在相关性。
