Al-Nowaiser Abeer M, Al-Zoman Hamad, Baskaradoss Jagan K, Robert Asirvatham A, Al-Zoman Khalid H, Al-Sohail Abdulaziz M, Al-Suwyed Abdulaziz S, Ciancio Sebastian G, Al-Mubarak Sultan A
Department of Preventive Dental Sciences, King Abdulaziz University, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Saudi Med J. 2014 Oct;35(10):1203-9.
To evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis.
This 9-month multi-center, randomized, parallel, single-blinded study was conducted from different hospitals in Riyadh, Saudi Arabia between April 2010 and December 2010. A total of 76 diabetic subjects with chronic periodontitis were randomized into 2 groups: control group (CG) received only scaling and root planing (SRP), and the treatment group (TG) receiving systemic doxycycline during the reevaluation visit 45 days after the completion of SRP. Probing pocket depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were collected at baseline, 45 days after SRP, and one, 3, and 6 months after the use of systemic doxycycline. Microbiological analysis comprised the detection of Tannerella forsythia (Tf), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi) by polymerase chain reaction method.
Sixty-eight (33 CG and 35 TG) subjects completed the study. Greater reduction in the population of Tf, Pg, and Pi were observed in TG compared with CG in the first month after the administration of systemic doxycycline. The TG showed a significant improvement in gingival index scores compared with the CG (p<0.05) by the end of the first and 6 months after the administration of doxycycline.
Adjunct systemic doxycycline can be associated with a reduction of Tf, Pg, and Pi in the first month after the administration of doxycycline with an improvement in the GI.
评估全身性强力霉素对慢性牙周炎糖尿病患者临床及微生物学参数的影响。
这项为期9个月的多中心、随机、平行、单盲研究于2010年4月至2010年12月在沙特阿拉伯利雅得的不同医院进行。共有76名患有慢性牙周炎的糖尿病患者被随机分为两组：对照组（CG）仅接受龈下刮治和根面平整（SRP），治疗组（TG）在SRP完成45天后的复诊时接受全身性强力霉素治疗。在基线、SRP后45天、使用全身性强力霉素后的1个月、3个月和6个月时收集探诊深度、临床附着水平、牙龈指数、菌斑指数和探诊出血情况。微生物学分析包括通过聚合酶链反应法检测福赛坦纳菌（Tf）、伴放线聚集杆菌（Aa）、牙龈卟啉单胞菌（Pg）和中间普氏菌（Pi）。
68名（33名CG和35名TG）受试者完成了研究。在给予全身性强力霉素后的第一个月，与CG相比，TG中Tf、Pg和Pi的数量减少得更多。在给予强力霉素后的第一个月末和6个月时，与CG相比，TG的牙龈指数评分有显著改善（p<0.05）。
辅助使用全身性强力霉素在给药后的第一个月可使Tf、Pg和Pi数量减少，牙龈指数得到改善。
