Xu Jinling, Zheng Jingwei, Yu Shujuan, Sun Zuhua, Zheng Weiwei, Qu Peng, Chen Yuanyuan, Chen Wuhe, Yu Xinping
Affiliate Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qilu Children's Hospital of Shandong University, Jinan, Shandong, China.
Invest Ophthalmol Vis Sci. 2014 Oct 14;55(11):7361-8. doi: 10.1167/iovs.14-14439.
To investigate the choroidal thickness (CT) in children with amblyopia through spectral-domain optical coherence tomography (SD-OCT).
Thirty-seven children with unilateral amblyopia and 22 children with normal vision participated in the study. Cross-sectional images of the choroid of evaluated eyes were obtained by SD-OCT. The choroidal thickness was measured directly below the fovea and at eight other locations: 1 and 2 mm superior, temporal, inferior, and nasal to the fovea. The researchers compared the choroidal thickness among amblyopic eyes, fellow eyes of children with amblyopia, and the eyes of children with normal vision. Age, sex, refractive error, axial length, and best-corrected visual acuity were also recorded. A paired t-test was used to compare measurements between amblyopic eyes and fellow eyes in patients with amblyopia. A generalized estimating equation (GEE) was used to compare measurements among amblyopic eyes, fellow eyes, and control eyes, adjusting for the possible effects of age, sex, and axial length on CT. The correlation between choroidal thickness and other continuous variables was determined using the Pearson correlation coefficient.
The choroidal thickness at the fovea, 1 and 2 mm superior, 1 mm inferior, 1 mm nasal, and 1 mm temporal to the fovea was greater in amblyopic eyes and in fellow eyes of children with amblyopia than in the eyes of children with normal vision. The choroidal thickness at the fovea and 2 mm nasal to the fovea in amblyopic eyes was greater (P = 0.002, P = 0.043) than in the fellow eyes of the children with amblyopia. The subfoveal CT in amblyopic eyes negatively correlated with axial length (r = -0.501, P = 0.002), but did not correlate with spherical equivalent, logMAR visual acuity, or age.
In the subfoveal area, the choroid was thicker in amblyopic eyes than in fellow eyes in children with amblyopia. Furthermore, differences were found in the choroidal thickness in both eyes of children with amblyopia compared with participants with normal vision. A thicker choroid is somehow related to amblyopia, and this may be a useful diagnostic parameter for amblyopia.
通过光谱域光学相干断层扫描（SD - OCT）研究弱视儿童的脉络膜厚度（CT）。
37名单侧弱视儿童和22名视力正常的儿童参与了该研究。通过SD - OCT获取被评估眼睛脉络膜的横断面图像。在黄斑中心凹正下方以及其他八个位置测量脉络膜厚度：黄斑中心凹上方、颞侧、下方和鼻侧1毫米及2毫米处。研究人员比较了弱视眼、弱视儿童的对侧眼以及视力正常儿童的眼睛的脉络膜厚度。还记录了年龄、性别、屈光不正、眼轴长度和最佳矫正视力。采用配对t检验比较弱视患者弱视眼与对侧眼的测量值。使用广义估计方程（GEE）比较弱视眼、对侧眼和对照眼的测量值，并对年龄、性别和眼轴长度对CT的可能影响进行校正。使用Pearson相关系数确定脉络膜厚度与其他连续变量之间的相关性。
弱视眼以及弱视儿童的对侧眼在黄斑中心凹、黄斑中心凹上方1毫米和2毫米、黄斑中心凹下方1毫米、黄斑中心凹鼻侧1毫米和黄斑中心凹颞侧1毫米处的脉络膜厚度大于视力正常儿童的眼睛。弱视眼在黄斑中心凹以及黄斑中心凹鼻侧2毫米处的脉络膜厚度大于弱视儿童的对侧眼（P = 0.002，P = 0.043）。弱视眼的黄斑中心凹下CT与眼轴长度呈负相关（r = - 0.501，P = 0.002），但与等效球镜度、logMAR视力或年龄无关。
在黄斑中心凹区域，弱视儿童的弱视眼脉络膜比其对侧眼厚。此外，与视力正常的参与者相比，弱视儿童双眼的脉络膜厚度存在差异。脉络膜增厚与弱视有一定关联，这可能是弱视的一个有用诊断参数。
