Aslan Bayhan Seray, Bayhan Hasan Ali
a Bozok University Faculty of Medicine , Ophthalmology Department , Yozgat , Turkey.
Curr Eye Res. 2017 Sep;42(9):1254-1259. doi: 10.1080/02713683.2017.1315141. Epub 2017 Jun 20.
To evaluate choroidal thickness (CT) in the eyes of children with hyperopic anisometropic amblyopia and to assess changes in CT during amblyopia treatment using spectral-domain optical coherence tomography (SD-OCT).
This longitudinal study, initially enrolled 40 patients, aged 3-9 years with hyperopic anisometropic amblyopia. Patients underwent treatment with refractive correction alone for 16 weeks and if needed, with refractive correction and patching treatment thereafter (6 months). CT was measured perpendicularly (from the outer edge of the hyper-reflective retinal pigment epithelium to the inner sclera) at the fovea, and 1.5-mm temporal, 3.0-mm temporal, 1.5-mm nasal, and 3.0-mm nasal to the fovea using SD-OCT in amblyopic eyes and fellow eyes during treatment and in the control subjects (n = 22).
The baseline subfoveal CT measurement was mean 367.9 ± 54 in the amblyopic eyes, 283.9 ± 39.6 in the fellow eyes, and 267.3 ± 41.3 µm in the control eyes. Before amblyopia treatment, the subfoveal CT and CT at 1.5-mm nasal and temporal to the fovea and 3.0-mm nasal to fovea in the amblyopic eyes were significantly thicker than those of the control subjects after adjustment for refraction and axial length by multivariate ANCOVA. CT at all locations decreased significantly after treatment in the amblyopic eyes. The final measurement of subfoveal choroid and CT at 1.5-mm nasal to the fovea of the amblyopic eyes was significantly thicker than those of the control subjects after adjusting for axial length and refraction.
The findings of this study indicate that children with hyperopic anisometropic amblyopia have significant CT alterations, and these changes partially regress after amblyopia treatment.
使用光谱域光学相干断层扫描（SD-OCT）评估远视性屈光参差性弱视儿童眼的脉络膜厚度（CT），并评估弱视治疗期间CT的变化。
这项纵向研究最初纳入了40例年龄在3至9岁的远视性屈光参差性弱视患者。患者先仅接受屈光矫正治疗16周，如有需要，此后再接受屈光矫正和遮盖治疗（6个月）。在治疗期间，使用SD-OCT在弱视眼及其对侧眼以及对照组（n = 22）中，于黄斑中心凹、黄斑中心凹颞侧1.5 mm、3.0 mm、黄斑中心凹鼻侧1.5 mm和3.0 mm处垂直测量CT（从高反射性视网膜色素上皮的外缘至巩膜内缘）。
弱视眼黄斑中心凹下CT测量的基线平均值为367.9±54 µm，对侧眼为283.9±39.6 µm，对照眼为267.3±41.3 µm。在弱视治疗前，经多变量协方差分析调整屈光和眼轴长度后，弱视眼黄斑中心凹下CT以及黄斑中心凹颞侧和鼻侧1.5 mm及鼻侧3.0 mm处的CT显著厚于对照组。弱视眼治疗后所有部位的CT均显著降低。在调整眼轴长度和屈光后，弱视眼黄斑中心凹下脉络膜的最终测量值以及黄斑中心凹鼻侧1.5 mm处的CT显著厚于对照组。
本研究结果表明，远视性屈光参差性弱视儿童存在显著的CT改变，且这些改变在弱视治疗后部分消退。
