安大略省西北部孕期麻醉品滥用的发生率：一项为期三年的前瞻性队列研究。
Incidence of narcotic abuse during pregnancy in northwestern Ontario: three-year prospective cohort study.
作者信息
Kelly Len, Guilfoyle John, Dooley Joe, Antone Irwin, Gerber-Finn Lianne, Dooley Roisin, Brunton Nicole, Kakegamuck Kara, Muileboom Jill, Hopman Wilma, Cromarty Helen, Linkewich Barb, Maki Jennifer
机构信息
Professor in the Division of Clinical Sciences at the Northern Ontario School of Medicine and a rural physician and clinical researcher in Sioux Lookout, Ont.
Assistant professor at Northern Ontario School of Medicine and rural family physician in Sioux Lookout.
出版信息
Can Fam Physician. 2014 Oct;60(10):e493-8.
OBJECTIVE
To document the incidence and outcomes of narcotic use during pregnancy in northwestern Ontario.
DESIGN
Three-year prospective cohort study.
SETTING
Sioux Lookout and surrounding communities in northwestern Ontario.
PARTICIPANTS
A total of 1206 consecutive births in a catchment area of 28 000 First Nations patients.
MAIN OUTCOME MEASURES
Incidence of narcotic use, and maternal and neonatal outcomes.
RESULTS
Incidence of narcotic use in pregnancy has risen to 28.6% (P < .001) and incidence of neonatal abstinence syndrome has fallen to 18.0% of narcotic-exposed births (P = .003). Daily intravenous drug use is now a common pattern of abuse.
CONCLUSION
Narcotic abuse in pregnancy has dramatically increased in northwestern Ontario. Neonatal outcomes have improved as a result of a family medicine-based prenatal and obstetric program that includes a narcotic replacement and tapering program.
目的
记录安大略省西北部地区孕期使用麻醉药品的发生率及后果。
设计
为期三年的前瞻性队列研究。
地点
安大略省西北部的苏圣玛丽及周边社区。
参与者
在一个拥有28000名原住民患者的集水区内连续出生的1206例婴儿。
主要观察指标
麻醉药品使用发生率、孕产妇及新生儿结局。
结果
孕期麻醉药品使用发生率已升至28.6%（P < 0.001），新生儿戒断综合征发生率已降至麻醉药品暴露分娩的18.0%（P = 0.003）。每日静脉注射吸毒如今是常见的滥用模式。
结论
安大略省西北部地区孕期麻醉药品滥用显著增加。由于一项基于家庭医学的产前和产科项目，包括麻醉药品替代及逐渐减量项目，新生儿结局有所改善。
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