Department of Psychiatry, Maulana Azad Medical College and G B Pant Hospital, New Delhi, India.
Department of Psychiatry, PGIMER and RML Hospital, New Delhi, India.
Indian J Psychiatry. 2014 Jul;56(3):298-300. doi: 10.4103/0019-5545.140654.
Kleine-Levin syndrome (KLS) alias sleeping beauty syndrome, is a rare sleep disorder. Clinically presenting as episodes of hypersomnolence, behavioral and cognitive disturbances, hyperphagia and hypersexuality. KLS may have an idiopathic onset or may be precipitated by neurological event or infection. Until date, no definite underlying cause is established and neither there are any definitive management guidelines. It remains a diagnosis of exclusion after other psychiatric and neurological causes have been ruled out. Coloring of presentation with behavioral and mood elements makes it important for a psychiatrist to be well-informed about the condition to avoid the erroneous diagnosis. KLS is a devastating illness, which robs the patient of time, experiences, and relationships. An early diagnosis and effective management can help patient escape from the morbidity caused by this disorder. Armodafinil and oxcarbamazepine have found to be effective in two of the case. The emphasis of this report is to add to the existing clinical knowledge of neurologists, psychiatrists and physicians. In the future, research is needed on genetic etiology and management of this disorder.
克莱恩-莱文综合征（Kleine-Levin syndrome，KLS），又名睡美人综合征，是一种罕见的睡眠障碍。其临床特征为发作性嗜睡、行为和认知障碍、食欲过盛和性欲亢进。KLS 可自发起病，也可由神经事件或感染诱发。迄今为止，尚未确定其明确的病因，也没有明确的治疗指南。在排除其他精神和神经科原因后，仍需进行排除性诊断。其临床表现伴有行为和情绪元素，这使得精神病医生充分了解该病症非常重要，以避免误诊。KLS 是一种破坏性疾病，使患者失去时间、经历和人际关系。早期诊断和有效管理可以帮助患者避免该疾病引起的发病。阿莫达非尼和奥卡西平已被证明对两种病例有效。本报告的重点是增加神经科医生、精神病医生和内科医生现有的临床知识。未来，需要对这种疾病的遗传病因和治疗进行研究。
