Tandon Vishal R, Sharma Sudhaa, Mahajan Annil
Department of Pharmacology, Government Medical College, Jammu and Kashmir, India.
Department of Obstetrics and Gynaecology, Government Medical College, Jammu and Kashmir, India.
J Midlife Health. 2014 Jul;5(3):111-4. doi: 10.4103/0976-7800.141186.
Bisphosphonates (BP) are the mainstay of treatment for osteoporosis. Subtrochanteric or diaphyseal fractures have been reported with long term use of BP, which raised world-wide debate on two aspects, i.e., for how long the BP is to be given and potential advantages/role of BP drug holidays. BP accumulates in bone with some persistent protective effect after therapy is stopped endorses the concept. Theoretically, a drug holiday may be a considerable option to decrease risks of BP, which continuing the protection from fractures but the level of evidence and data supporting the concept of drug holidays is a week. Hence, no specific recommendations are available on BP drug holidays from major available treatment guidelines on postmenopausal osteoporosis. Hence, before it is recommended it requires more robust research in this field.
双膦酸盐（BP）是骨质疏松症治疗的主要药物。长期使用BP后有粗隆下或骨干骨折的报道，这在全球引发了两方面的争论，即BP应使用多长时间以及BP药物假期的潜在益处/作用。治疗停止后BP在骨中蓄积并具有一定的持续保护作用，这支持了该概念。理论上，药物假期可能是降低BP风险的一个相当不错的选择，既能持续预防骨折，又能降低BP风险，但支持药物假期概念的证据水平和数据较少。因此，绝经后骨质疏松症的主要现有治疗指南中没有关于BP药物假期的具体建议。因此，在推荐之前，该领域需要更有力的研究。
