Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Curr Osteoporos Rep. 2018 Jun;16(3):299-311. doi: 10.1007/s11914-018-0443-y.
This review examines recent literature regarding the clinical management of fragility fractures, provides insight into new practice patterns, and discusses controversies in current management.
There are declining rates of osteoporosis management following initial fragility fracture. Management of osteoporotic fractures via a multidisciplinary team reduces secondary fracture incidence and improves overall osteoporotic care. Anabolic agents (abaloparatide and teriparatide) are effective adjuvants to fracture repair, and have shown positive results in cases of re-fracture in spite of medical management (i.e., bisphosphonates). For AO 31-A1 and A2 intertrochanteric hip fractures (non-reverse obliquity), no clinical advantage of intramedullary fixation over the sliding hip screw (SHS) has been proven; SHS is more cost-effective. As fragility fracture incidence continues to rise, orthopedic surgeons must play a more central role in the care of osteoporotic patients. Initiation of pharmacologic intervention is key to preventing subsequent fragility fractures, and may play a supportive role in initial fracture healing. While the media bombards patients with complications of medical therapy (atypical femur fractures, osteonecrosis of jaw, myocardial infarction), providers need to understand and communicate the low incidence of these complications compared with consequences of not initiating medical therapy.
本篇综述探讨了脆性骨折的临床管理方面的最新文献,深入了解新的实践模式,并讨论了当前管理中的争议。
初始脆性骨折后,骨质疏松症的管理率呈下降趋势。通过多学科团队对骨质疏松性骨折进行管理,可降低二次骨折的发生率,并改善整体骨质疏松症的护理水平。合成代谢药物(abaloparatide 和 teriparatide)是骨折修复的有效辅助药物,在药物治疗(即双膦酸盐)的情况下再次骨折时,结果显示为阳性。对于 AO 31-A1 和 A2 型股骨转子间骨折(非反斜型),髓内固定与滑动髋螺钉(SHS)相比,并没有临床优势;SHS 更具成本效益。随着脆性骨折发病率的持续上升,矫形外科医生必须在骨质疏松症患者的护理中发挥更核心的作用。开始药物干预是预防后续脆性骨折的关键,并且可能在初始骨折愈合中起辅助作用。虽然媒体向患者大肆宣传药物治疗的并发症(非典型股骨骨折、颌骨骨坏死、心肌梗死),但提供者需要了解并传达与不开始药物治疗相比,这些并发症的发生率较低。