卵巢衰老与卵巢早衰
Ovarian aging and premature ovarian failure.
作者信息
Sükür Yavuz Emre, Kıvançlı Içten Balık, Ozmen Batuhan
机构信息
Department of Obstetrics and Gynecology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Department of Obstetrics and Gynecology, Gazimagusa State Hospital, Gazimagusa, Turkish Republic of Northern Cyprus.
出版信息
J Turk Ger Gynecol Assoc. 2014 Aug 8;15(3):190-6. doi: 10.5152/jtgga.2014.0022. eCollection 2014.
Abstract
Physiological reproductive aging occurs as a result of a decrease in the number and quality of oocytes in ovarian cortex follicles. Although the reason for the decrease in the quality of the pool and follicular oocytes is not fully understood, endocrine, paracrine, genetic, and metabolic factors are thought to be effective. Nowadays, in order to understand the mechanisms of ovarian aging, genomic research has gained importance. The effect of co-factors, such as telomerase and ceramide, in the ovarian aging process is only getting ascertained with new research studies. The most important tests in the assessment of ovarian aging are antral follicle count and anti-Mullerian hormone.
摘要
生理性生殖衰老的发生是由于卵巢皮质卵泡中卵母细胞数量和质量下降所致。尽管卵泡池中卵泡和卵母细胞质量下降的原因尚未完全明确，但内分泌、旁分泌、遗传和代谢因素被认为有影响。如今，为了了解卵巢衰老的机制，基因组研究变得愈发重要。端粒酶和神经酰胺等辅助因子在卵巢衰老过程中的作用，只是通过新的研究才刚刚得以确定。评估卵巢衰老最重要的检查是窦卵泡计数和抗苗勒管激素。
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