Kapson Blaire, Nayar Sumiti, Spiegel Rebecca
Stony Brook Department of Neurology, Stony Brook, NY.
Stony Brook Department of Neurology, Stony Brook, NY ; Stony Brook University Sleep Disorder Center, Stony Brook, NY.
J Clin Sleep Med. 2014 Oct 15;10(10):1153-4. doi: 10.5664/jcsm.4124.
Kleine-Levin syndrome (KLS) is a rare and disabling disorder characterized by recurrent episodes of hypersomnia as well as cognitive and behavioral abnormalities. Sadly, the treatment options are very limited and often ineffective. To our knowledge, there have been no reports in the literature for the use of acetazolamide as a treatment for this disorder. We report the case of a 26-year-old female patient with KLS in whom acetazolamide was used to treat recurrent hypersomnia and cognitive abnormalities. The patient had a dramatic improvement on acetazolamide in both the frequency and severity of her symptoms. The symptoms recurred when acetazolamide was stopped on two occasions and improved with resumption of the drug, leading us to conclude that its therapeutic effect was significant.
克莱恩-莱文综合征（KLS）是一种罕见的致残性疾病，其特征为反复发作的嗜睡以及认知和行为异常。遗憾的是，治疗选择非常有限且往往无效。据我们所知，文献中尚无使用乙酰唑胺治疗该疾病的报道。我们报告了一例26岁患有KLS的女性患者，使用乙酰唑胺治疗其反复发作的嗜睡和认知异常。该患者使用乙酰唑胺后症状的频率和严重程度均有显著改善。有两次停用乙酰唑胺时症状复发，恢复用药后症状改善，这使我们得出结论，其治疗效果显著。
