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电针对脑缺血再灌注损伤后血脑屏障损伤的保护作用。

Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/ reperfusion injury.

机构信息

Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

出版信息

Neural Regen Res. 2012 Dec 25;7(36):2901-6. doi: 10.3969/j.issn.1673-5374.2012.36.007.

DOI:10.3969/j.issn.1673-5374.2012.36.007
PMID:25317142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4190948/
Abstract

This study used electroacupuncture at Renzhong (DU26) and Baihui (DU20) in a rat model of cerebral ischemia/reperfusion injury. Neurological deficit scores, western blotting, and reverse transcription-PCR results demonstrated that electroacupuncture markedly reduced neurological deficits, decreased corpus striatum aquaporin-4 protein and mRNA expression, and relieved damage to the blood-brain barrier in a rat model of cerebral ischemia/reperfusion injury. These results suggest that electroacupuncture most likely protects the blood-brain barrier by regulating aquaporin-4 expression following cerebral ischemia/reperfusion injury.

摘要

本研究采用电针对脑缺血再灌注损伤大鼠模型的人中（DU26）和百会（DU20）进行刺激。神经功能缺损评分、Western blot 和逆转录-PCR 结果表明，电针对脑缺血再灌注损伤大鼠模型的神经功能缺损有明显改善作用，降低纹状体水通道蛋白-4 蛋白和 mRNA 的表达，减轻血脑屏障损伤。这些结果表明，电针可能通过调节脑缺血再灌注损伤后水通道蛋白-4 的表达来保护血脑屏障。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe3/4190948/45426c1e4425/NRR-7-2901-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe3/4190948/718b035cddf1/NRR-7-2901-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe3/4190948/1c644fb7ab1a/NRR-7-2901-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe3/4190948/45426c1e4425/NRR-7-2901-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe3/4190948/718b035cddf1/NRR-7-2901-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe3/4190948/1c644fb7ab1a/NRR-7-2901-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffe3/4190948/45426c1e4425/NRR-7-2901-g005.jpg

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本文引用的文献

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Aquaporins: multifarious roles in brain.水通道蛋白：在大脑中的多种作用。
Neuroscience. 2010 Jul 28;168(4):859-61. doi: 10.1016/j.neuroscience.2010.04.071. Epub 2010 May 5.
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Regulation of water permeability through aquaporin-4.水通道蛋白-4 对水通透性的调节。
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Structure and function of the blood-brain barrier.血脑屏障的结构和功能。
Mechanisms Involved in the Neuroprotection of Electroacupuncture Therapy for Ischemic Stroke.
电针疗法对缺血性中风神经保护作用的相关机制
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Neuronal Regeneration after Electroacupuncture Treatment in Ischemia-Reperfusion-Injured Cerebral Infarction Rats.电针对脑缺血再灌注损伤大鼠神经元再生的影响。
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Electroacupuncture preconditioning reduces ROS generation with NOX4 down-regulation and ameliorates blood-brain barrier disruption after ischemic stroke.电针预处理通过下调NOX4减少活性氧生成，并改善缺血性中风后的血脑屏障破坏。
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[Regulative effect of electroacupuncture on aquaporin-4 in rats with focal cerebral ischemia/reperfusion].电针对局灶性脑缺血/再灌注大鼠水通道蛋白4的调节作用
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Pathophysiology of traumatic brain injury.创伤性脑损伤的病理生理学
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Time course of aquaporin expression after transient focal cerebral ischemia in mice.小鼠短暂性局灶性脑缺血后水通道蛋白表达的时间进程。
J Neurosci Res. 2006 May 15;83(7):1231-40. doi: 10.1002/jnr.20819.
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