Diagnostic Neuroimaging, Department of Psychiatry, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84108, USA.
George E. Wahlen Veterans Affairs Medical Center, 500 Foothill Drive, Salt Lake City, UT 84148, USA.
Biomolecules. 2019 Aug 23;9(9):406. doi: 10.3390/biom9090406.
Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditions, represents a serious threat to public health and wellness. Conventional treatments are not effective for a significant proportion of patients and interventions that are often beneficial for treatment-refractory depression are not widely available. There is, therefore, an immense need to identify novel antidepressant strategies, particularly strategies that target physiological pathways that are distinct from those addressed by conventional treatments. There is growing evidence from human neuroimaging, genetics, epidemiology, and animal studies that disruptions in brain energy production, storage, and utilization are implicated in the development and maintenance of depression. Creatine, a widely available nutritional supplement, has the potential to improve these disruptions in some patients, and early clinical trials indicate that it may have efficacy as an antidepressant agent.
抑郁情绪可能出现在重性抑郁障碍、双相障碍和其他疾病中，它对公众健康和福祉构成了严重威胁。常规治疗对相当一部分患者无效，而对于治疗抵抗性抑郁症往往有益的干预措施并不广泛。因此，迫切需要确定新的抗抑郁策略，特别是针对与常规治疗不同的生理途径的策略。越来越多的来自人类神经影像学、遗传学、流行病学和动物研究的证据表明，大脑能量产生、储存和利用的中断与抑郁症的发展和维持有关。肌酸是一种广泛可用的营养补充剂，它有可能改善一些患者的这些中断，早期临床试验表明它可能具有抗抑郁作用。
