Laboratory of Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine CONICET, Vuelta de Obligado 2490, Buenos Aires, Argentina ; Departament of Human Biochemistry, School of Medicine, Buenos Aires University, Paraguay 2155, Buenos Aires, Argentina.
Neuroinflammation Laboratory, National Hospital For Paraplegics, (SESCAM), Toledo, Spain.
Neural Regen Res. 2014 Aug 1;9(15):1422-4. doi: 10.4103/1673-5374.139456.
There is currently no standard pharmacological treatment for spinal cord injury. Here, we suggest that progesterone, a steroid hormone, may be a promising therapeutical candidate as it is already for traumatic brain injury, where it has reached phase II clinical trials. We rely on previous works showing anti-inflammatory, neuroprotective and promyelinating roles for progesterone after spinal cord injury and in our recent paper, in which we demonstrate that progesterone diminishes lesion, preserves white matter integrity and improves locomotor recovery in a clinically relevant model of spinal cord lesion.
目前，脊髓损伤还没有标准的药物治疗方法。在这里，我们建议孕激素（一种甾体激素）可能是一种很有前途的治疗候选药物，因为它已经在创伤性脑损伤中进行了 II 期临床试验。我们依赖于以前的研究结果，这些结果表明孕激素在脊髓损伤后具有抗炎、神经保护和促进髓鞘形成的作用，并且在我们最近的研究中，我们证明了孕激素可以减少损伤、保持白质完整性并改善临床相关的脊髓损伤模型中的运动功能恢复。
