柚皮苷（葡萄柚和柑橘类水果中的一种类黄酮糖苷）对成年大脑黑质纹状体多巴胺能投射的影响。
Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain.
机构信息
Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea.
School of Life Sciences, Kyungpook National University, Daegu, Korea ; BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea ; Institute of Life Science & Biotechnology, Kyungpook National University, Daegu, Korea ; Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea.
出版信息
Neural Regen Res. 2014 Aug 15;9(16):1514-7. doi: 10.4103/1673-5374.139476.
Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruits, to prevent neurodegeneration in a neurotoxin model of Parkinson's disease. Intraperitoneal injection of naringin protected the nigrostriatal dopaminergic projection by increasing glial cell line-derived neurotrophic factor expression and decreasing the level of tumor necrosis factor-alpha in dopaminergic neurons and microglia, respectively. These results suggest that naringin can impart to the adult dopaminergic neurons the ability to produce glial cell line-derived neurotrophic factor against Parkinson's disease with anti-inflammatory effects. Based on these results, we would like to describe an important perspective on its possibility as a therapeutic agent for Parkinson's disease.
最近，我们已经证明了柚皮苷（葡萄柚和柑橘类水果中的一种众所周知的类黄酮糖苷）预防帕金森病神经毒素模型中神经退行性变的能力。柚皮苷的腹腔注射通过分别增加胶质细胞系源性神经营养因子表达和降低多巴胺神经元和小胶质细胞中肿瘤坏死因子-α的水平来保护黑质纹状体多巴胺能投射。这些结果表明，柚皮苷可以使成年多巴胺能神经元产生胶质细胞系源性神经营养因子，从而发挥抗炎作用，对抗帕金森病。基于这些结果，我们希望描述其作为帕金森病治疗剂的可能性的一个重要观点。
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