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胰岛素瘤：年轻女性低血糖的罕见病因。

Insulinoma: A rare cause of hypoglycemia in a young female.

作者信息

Kelash Fnu, Mulinda James

机构信息

Carilion Clinic, Roanoke, VA, USA.

出版信息

J Community Hosp Intern Med Perspect. 2014 Sep 29;4(4). doi: 10.3402/jchimp.v4.25093. eCollection 2014.

DOI:10.3402/jchimp.v4.25093
PMID:25317264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4185142/
Abstract

Insulinoma is an exceedingly uncommon pancreatic islet cell neuroendocrine tumor. The estimated incidence is approximately four cases per million individuals per year and accounts for 60% of islets cell tumors. It causes glycopenic symptoms which includes headache, feeling irritable, confused, seizure or coma and leads to catecholamine excess which includes rapid heartbeat, sweating, palpitations and feelings of hunger. Early detection of the tumor prevents recurrent episodes of lethal hypoglycemia.

摘要

胰岛素瘤是一种极为罕见的胰岛细胞神经内分泌肿瘤。估计发病率约为每年每百万人中有4例，占胰岛细胞瘤的60%。它会引发低血糖症状，包括头痛、易怒、意识模糊、癫痫发作或昏迷，并导致儿茶酚胺过量，包括心跳加速、出汗、心悸和饥饿感。肿瘤的早期发现可预防致命性低血糖的反复发作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d62/4185142/ccc47bc43f6b/JCHIMP-4-25093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d62/4185142/a21ef69f4552/JCHIMP-4-25093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d62/4185142/ccc47bc43f6b/JCHIMP-4-25093-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d62/4185142/a21ef69f4552/JCHIMP-4-25093-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d62/4185142/ccc47bc43f6b/JCHIMP-4-25093-g002.jpg

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引用本文的文献

1
Editor's note.编者按。
J Community Hosp Intern Med Perspect. 2014 Sep 29;4(4). doi: 10.3402/jchimp.v4.25955. eCollection 2014.

本文引用的文献

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Insulinoma: case report and review of diagnostic and treatment modalities.胰岛素瘤：病例报告及诊断与治疗方式综述
J Assoc Physicians India. 2013 Jun;61(6):423-6.
2
Insulinoma diagnosed as drug-refractory epilepsy in an adolescent boy: a case report.青少年男性胰岛素瘤误诊为难治性癫痫1例报告
Rom J Morphol Embryol. 2013;54(4):1147-51.
3
A case of malignant insulinoma: successful control of glycemic fluctuation by replacing octreotide injections with octreotide LAR injections.胰岛素瘤恶变 1 例：用奥曲肽长效释放微球替代奥曲肽注射控制血糖波动获得成功
Endocr J. 2013;60(8):951-7. doi: 10.1507/endocrj.ej13-0025. Epub 2013 May 11.
4
Chronic progressive encephalopathy, intractable seizures, and neuropathy: a triad of neurological features in insulinoma.慢性进行性脑病、难治性癫痫和神经病变：胰岛素瘤的三联征神经学特征。
Neurol India. 2012 Mar-Apr;60(2):238-9. doi: 10.4103/0028-3886.96422.
5
Laparoscopic radiofrequency ablation of neuroendocrine liver metastases: a 10-year experience evaluating predictors of survival.腹腔镜射频消融治疗神经内分泌肝转移瘤：一项评估生存预测因素的10年经验
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Complete clinical remission and disappearance of liver metastases after treatment with somatostatin analogue in a 40-year-old woman with a malignant insulinoma positive for somatostatin receptors type 2.一名40岁患有对2型生长抑素受体呈阳性的恶性胰岛素瘤的女性，在接受生长抑素类似物治疗后实现了完全临床缓解且肝转移灶消失。
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J Am Coll Surg. 2003 Jul;197(1):29-37. doi: 10.1016/S1072-7515(03)00230-8.
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Postgrad Med J. 1997 Oct;73(864):640-1. doi: 10.1136/pgmj.73.864.640.
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