Rayegani Seyed Mansoor, Raeissadat Seyed Ahmad, Taheri Morteza Sanei, Babaee Marzieh, Bahrami Mohammad Hassan, Eliaspour Dariush, Ghorbani Elham
Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish Hospital , Tehran, Iran.
Physical Medicine and Rehabilitation Department, Shahid Modarres Hospital , Tehran, Iran.
Orthop Rev (Pavia). 2014 Sep 18;6(3):5405. doi: 10.4081/or.2014.5405. eCollection 2014 Aug 8.
We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University's Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.
我们设计了一项设有对照组的随机临床试验，以研究富含血小板血浆（PRP）对膝骨关节炎患者疼痛、僵硬、功能及生活质量的影响。患者被随机分为两组。两组参与者均接受规定的治疗性锻炼。在PRP组中，注射两疗程富含白细胞的PRP（血小板浓度高5.6倍），间隔4周。对每位参与者，在基线期及治疗后6个月填写西安大略和麦克马斯特大学骨关节炎指数（WOMAC）及SF-36问卷（波斯语版）。对PRP组的31例患者和对照组的31例患者进行了研究。PRP组中WOMAC总分、简明健康状况调查简表（SF-36）的身体成分得分和心理成分得分的平均变化显示比对照组有更好的改善（P<0.05）。本研究表明，与单纯治疗性锻炼相比，关节内注射PRP联合治疗性锻炼在减轻疼痛、改善僵硬及生活质量方面可能更有效。
