Institute of Orthopedics, Chinese PLA General Hospital, Fuxing 28# Road, Beijing 100853, China.
Osteoarthritis Cartilage. 2013 Nov;21(11):1627-37. doi: 10.1016/j.joca.2013.07.017. Epub 2013 Aug 7.
Cartilage defects (CDs) and the most common joint disease, osteoarthritis (OA), are characterized by degeneration of the articular cartilage that ultimately leads to joint destruction. Current treatment strategies are inadequate: none results in restoration of fully functional hyaline cartilage, for uncertain long-term prognosis. Tissue engineering of cartilage with auto-cartilage cells or appropriate mesenchymal stem cell (MSC)-derived cartilage cells is currently being investigated to search for new therapies. Platelet-rich plasma (PRP), an autologous source of factors obtained by centrifugation, possesses various functions. For culture of MSCs and cartilage cells, it might be substituted for fetal bovine serum (FBS) with high efficiency and safety. It enhances the regeneration of cartilage cells when added to cartilage tissue engineering constructs for repairing CDs and as regenerative injection therapy for OA. But challenges also remain. Some of the growth factors (GFs) present in PRP have negative effects on the OA joint. It is therefore unlikely that a mix of GFs some of which have negative effects in the OA joint, as present in PRP, will be of benefit in OA. Future directions of PRP application may concentrate on seeking an appropriate and innocuous agent like anti-VEGF antibody that can modulate and control the effect of PRP.
软骨缺损（CDs）和最常见的关节疾病骨关节炎（OA）的特征是关节软骨退化，最终导致关节破坏。目前的治疗策略并不完善：没有一种方法能完全恢复透明软骨的功能，而且预后也不确定。目前正在研究用自体软骨细胞或适当的间充质干细胞（MSC）来源的软骨细胞进行软骨组织工程，以寻找新的治疗方法。富含血小板的血浆（PRP）是通过离心获得的自体来源的因子，具有多种功能。用于培养 MSC 和软骨细胞时，它可以高效、安全地替代胎牛血清（FBS）。当添加到修复 CDs 的软骨组织工程构建物中或作为 OA 的再生注射治疗时，它可以增强软骨细胞的再生。但挑战仍然存在。PRP 中存在的一些生长因子（GFs）对 OA 关节有负面影响。因此，PRP 中存在的混合 GFs （其中一些对 OA 关节有负面影响）不太可能对 OA 有益。PRP 应用的未来方向可能集中在寻找一种合适且无害的药物，如抗 VEGF 抗体，以调节和控制 PRP 的作用。
