Nourse Rosemary, Reade Cynthia, Stoltzfus Jill, Mittal Vikrant
Department of Psychiatry (Ms Nourse), Behavioral Health Services (Dr Mittal and Ms Reade) and Research Institute (Dr Stoltzfus), St Luke's University Hospital, Bethlehem, Pennsylvania.
Prim Care Companion CNS Disord. 2014;16(3). doi: 10.4088/PCC.13m01589. Epub 2014 Jun 5.
Aggressive patients are not uncommon in acute inpatient behavioral health units of general hospitals. Prior research identifies various predictors associated with aggressive inpatient behavior. This prospective observational study examines the demographic and clinical characteristics of aggressive inpatients and the routine medications these patients were receiving at discharge.
Thirty-six adults diagnosed with a DSM-IV mental disorder who met 2 of 6 established inclusion criteria for high violence risk and a Clinical Global Impressions-Severity of Illness (CGI-S) scale score ≥ 4 were observed for a maximum of 28 days on the 23-bed case mix acute behavioral health unit of St Luke's University Hospital, Bethlehem, Pennsylvania, from January 2012 to May 2013. Primary outcome measures were the Modified Overt Aggression Scale (MOAS) and CGI-S; secondary measures were symptom outcome measures and demographic and clinical characteristics data. Analysis was conducted using repeated measures methodology.
Younger males with a history of previous violence, psychiatric admissions, and symptoms of severe agitation were more at risk for aggressive behavior. Positive psychotic symptoms, a diagnosis of bipolar disorder, substance use, and comorbid personality disorders also increased risk. Significant improvements from baseline to last visit were observed for the CGI-S and MOAS (P < .001 for both), with a significant correlation between the MOAS and CGI-S at last visit (P < .001). Only the symptom of agitation was significantly correlated to MOAS scores at both baseline and last visit (P < .001).
Patients significantly improved over time in both severity of illness and level of aggression.
在综合医院的急性住院行为健康单元中,具有攻击性行为的患者并不少见。先前的研究确定了与住院患者攻击性行为相关的各种预测因素。这项前瞻性观察性研究调查了具有攻击性行为的住院患者的人口统计学和临床特征,以及这些患者出院时正在服用的常规药物。
2012年1月至2013年5月期间,在宾夕法尼亚州伯利恒市圣卢克大学医院拥有23张床位的病例组合急性行为健康单元,对36名被诊断患有DSM-IV精神障碍、符合6项既定高暴力风险纳入标准中的2项且临床总体印象-疾病严重程度(CGI-S)量表评分≥4的成年人进行了为期最多28天的观察。主要结局指标为改良外显攻击量表(MOAS)和CGI-S;次要指标为症状结局指标以及人口统计学和临床特征数据。采用重复测量方法进行分析。
有既往暴力史、精神科住院史以及严重激越症状的年轻男性更易出现攻击性行为。阳性精神病性症状、双相情感障碍诊断、物质使用以及共病的人格障碍也会增加风险。从基线到最后一次访视,CGI-S和MOAS均有显著改善(两者P均<.001),最后一次访视时MOAS与CGI-S之间存在显著相关性(P<.001)。仅激越症状在基线和最后一次访视时均与MOAS评分显著相关(P<.001)。
随着时间推移,患者在疾病严重程度和攻击水平方面均有显著改善。