与T细胞淋巴瘤相关的噬血细胞性淋巴组织细胞增生症（HLH）：拓宽不明原因发热的鉴别诊断范围
Hemophagocytic Lymphohistiocytosis (HLH) Associated with T-Cell Lymphomas: Broadening our Differential for Fever of Unknown Origin.
作者信息
Khadanga Sherrie, Solomon Benjamin, Dittus Kim
机构信息
Department of Medicine, University of Vermont, Vermont, USA.
Division of Hematology/Oncology, University of Vermont, Vermont, USA.
出版信息
N Am J Med Sci. 2014 Sep;6(9):484-6. doi: 10.4103/1947-2714.141656.
CONTEXT
Hemophagocytic lymphohistiocytosis (HLH), due to the excessive activity of histiocytes and lymphocytes, is a rare but aggressive disease that typically occurs in infancy but can be seen in all ages. If left untreated, patients with HLH may live for only a few months and die from multi-organ failure.
CASE REPORT
We present two cases of HLH diagnosis. Fever, spleen, and hepatic abnormalities were noted in both cases.
CONCLUSION
Early diagnosis is the key and these two cases of similar etiology highlight how fever of unknown origin should force us to broaden our differential.
背景
噬血细胞性淋巴组织细胞增生症（HLH）由于组织细胞和淋巴细胞过度活跃，是一种罕见但侵袭性的疾病，通常发生于婴儿期，但各年龄段均可出现。若不治疗，HLH患者可能仅存活数月并死于多器官功能衰竭。
病例报告
我们呈现两例HLH诊断病例。两例均有发热、脾脏及肝脏异常表现。
结论
早期诊断是关键，这两例病因相似的病例凸显了不明原因发热如何促使我们扩大鉴别诊断范围。
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