Hemophagocytic Lymphohistiocytosis (HLH) Associated with T-Cell Lymphomas: Broadening our Differential for Fever of Unknown Origin.

CONTEXT

Hemophagocytic lymphohistiocytosis (HLH), due to the excessive activity of histiocytes and lymphocytes, is a rare but aggressive disease that typically occurs in infancy but can be seen in all ages. If left untreated, patients with HLH may live for only a few months and die from multi-organ failure.

CASE REPORT

We present two cases of HLH diagnosis. Fever, spleen, and hepatic abnormalities were noted in both cases.

CONCLUSION

Early diagnosis is the key and these two cases of similar etiology highlight how fever of unknown origin should force us to broaden our differential.