Montgomery S A, Gabriel R, James D, Hawley C, Burkitt P
St Mary's Hospital Medical School, London.
Int Clin Psychopharmacol. 1989 Jan;4(1):19-23. doi: 10.1097/00004850-198901000-00003.
The first of a series of 5HT reuptake inhibitors, zimelidine was withdrawn because of associated hypersensitivity reactions. There was concern that such reactions might be seen with other compounds of this class. Two depressed patients who had a sensitivity reaction to treatment with zimelidine were crossed over to treatment with fluoxetine and no abnormalities were observed. Both patients remained well during uneventful long term treatment with fluoxetine.
作为5-羟色胺再摄取抑制剂系列中的首个药物，齐美利定因相关的过敏反应而被撤市。人们担心这类反应可能会出现在该类别的其他化合物中。两名对齐美利定治疗产生过敏反应的抑郁症患者转而接受氟西汀治疗，未观察到异常情况。在氟西汀的长期平稳治疗期间，两名患者均状况良好。
