Wu S-F, Zhu Z-F, Kong Y, Zhang H-P, Zhou G-Q, Jiang Q-T, Meng X-P
Department of Neurology, Affiliated Jiangyin Hospital Medical College of Southeast University, Jiangyin Jiangsu Province, China.
Eur Rev Med Pharmacol Sci. 2014;18(18):2605-8.
The overall goal of this study was to evaluate the usability of the susceptibility weighted imaging (SWI) in (1) assessment of iron deposition to enhance our ability to detect PD in the early phase and (2) in estimation of the degree of PD.
SWI scans were carried out in 54 patients with PD (18 patients with the Hoehn-Yahr scale < 1.5 and 36 patients with the Hoehn-Yahr stage > 1.5) and 40 control individuals. The phase values of the substantia nigra, red nucleus, caudate nucleus, putamen, and globus pallidus were measured on the corrected phase image.
Compared with control individuals, patients with both the early and intermediate/ advanced stages of PD had significantly different phase values in the substantia nigra, red nucleus, caudate nucleus, putamen, and globus pallidus (all p < 0.05). The phase values of the substantia nigra and globus pallidus inversely correlated with the Hoehn-Yahr scale (respectively, r = -0.845, p < 0.05, and r = -0.868, p < 0.05). Weaker correlations were found between the phase values of red nucleus, caudate nucleus, putamen, and Hoehn-Yahr scale (red nucleus r = -0.543, caudate nucleus r = -0.620, p < 0.05, putamen r = -0.537).
A semi-quantitative assessment of the iron content of the substantia nigra and globus pallidus with the help of SWI may be useful for early diagnosis of PD and evaluation of the degree of this disease.
本研究的总体目标是评估磁敏感加权成像（SWI）在以下两方面的可用性：（1）评估铁沉积，以提高我们在早期检测帕金森病（PD）的能力；（2）估计PD的程度。
对54例PD患者（18例Hoehn-Yahr分级<1.5，36例Hoehn-Yahr分期>1.5）和40例对照个体进行SWI扫描。在校正后的相位图像上测量黑质、红核、尾状核、壳核和苍白球的相位值。
与对照个体相比，PD早期和中期/晚期患者的黑质、红核、尾状核、壳核和苍白球的相位值均有显著差异（均p<0.05）。黑质和苍白球的相位值与Hoehn-Yahr分级呈负相关（分别为r=-0.845，p<0.05；r=-0.868，p<0.05）。红核、尾状核、壳核的相位值与Hoehn-Yahr分级之间的相关性较弱（红核r=-0.543，尾状核r=-0.620，p<0.05，壳核r=-0.537）。
借助SWI对黑质和苍白球铁含量进行半定量评估，可能有助于PD的早期诊断和病情程度评估。
