Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Brain Res. 2010 May 12;1330:124-30. doi: 10.1016/j.brainres.2010.03.036. Epub 2010 Mar 18.
Brain-iron deposition has been proposed to play an important role in the pathophysiology of Parkinson's disease (PD). The aim of this study was to evaluate the feasibility of characterizing iron deposition in PD using susceptibility-weighted imaging (SWI), and to investigate the correlation of brain-iron accumulation with the clinical status in patients with PD. Forty patients with PD without dementia and 26 age- and sex-matched healthy controls underwent high-resolution susceptibility-weighted magnetic resonance (MR) imaging. The phase shift values of the bilateral red nucleus (RN), substantia nigra (SN), caudate nucleus (CA), globus pallidus (GP), putamen (PU), thalamus (TH) and frontal white matter (FWM) were examined for their relationship with the clinical status. The iron concentrations of the regions involved in PD, such as the SN, increased more significantly, while those in other regions of interest (ROI) did not elevate significantly. No correlation between the increase of the iron concentrations of the SN and duration of PD was observed. PD, however, was closely associated with the Unified Parkinson's Disease Rating Scale motor score (UPDRS-III). No significant differences were found between earlier-onset and later-onset PD patients in terms of the iron concentrations of the SN. Brain-iron concentration can be evaluated by SWI. Also, the brain-iron concentration in the SN correlated with UPDRS motor score, indicating that iron concentration can function as an in vivo biomarker to objectively evaluate the status of PD.
脑铁沉积被认为在帕金森病(PD)的病理生理学中起重要作用。本研究旨在评估使用磁敏感加权成像(SWI)来描述 PD 患者铁沉积的可行性,并研究脑铁积累与 PD 患者临床状况的相关性。40 名无痴呆的 PD 患者和 26 名年龄和性别匹配的健康对照者接受了高分辨率磁敏感加权磁共振(MR)成像。检查双侧红核(RN)、黑质(SN)、尾状核(CA)、苍白球(GP)、壳核(PU)、丘脑(TH)和额白质(FWM)的相位偏移值与临床状况的关系。参与 PD 的区域(如 SN)的铁浓度增加更为显著,而其他感兴趣区域(ROI)的铁浓度没有明显升高。SN 中铁浓度的增加与 PD 持续时间之间没有相关性。然而,PD 与帕金森病统一评定量表运动评分(UPDRS-III)密切相关。在 SN 中铁浓度方面,早发性和晚发性 PD 患者之间没有发现显著差异。SWI 可评估脑铁浓度。此外,SN 中的脑铁浓度与 UPDRS 运动评分相关,表明铁浓度可以作为一种体内生物标志物,客观地评估 PD 的状况。