State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Food Funct. 2014 Dec;5(12):3216-23. doi: 10.1039/c4fo00549j.
The effect of Lactobacillus plantarum NCU116 on liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease (NAFLD) was studied. The rats were divided into four groups: the normal diet (ND) group; the high fat diet (HFD) group; and HFD plus L. plantarum NCU116 as two doses (NCU116-L, 10(8) CFU mL(-1); NCU116-H, 10(9) CFU mL(-1)) groups. Treatment of L. plantarum NCU116 for 5 weeks was found to restore liver function and oxidative stress in rats with NAFLD, and decrease the levels of fat accumulation in the liver. In addition, the bacterium significantly reduced endotoxin and proinflammatory cytokines, and regulated bacterial flora in the colon and the expression of lipid metabolism in the liver. These results suggest that possible underlying mechanisms for the beneficial effect of L. plantarum NCU116 on NAFLD may include two pathways of downregulating lipogenesis and upregulating lipolysis and fatty acid oxidation related gene expression.
研究了植物乳杆菌 NCU116 对高脂肪饮食诱导的非酒精性脂肪肝病（NAFLD）大鼠肝功能、氧化应激和脂质代谢的影响。将大鼠分为四组：正常饮食（ND）组；高脂肪饮食（HFD）组；和 HFD 加两种剂量的植物乳杆菌 NCU116（NCU116-L，10(8) CFU mL(-1)；NCU116-H，10(9) CFU mL(-1))组。用植物乳杆菌 NCU116 治疗 5 周可恢复 NAFLD 大鼠的肝功能和氧化应激，并降低肝脏脂肪堆积水平。此外，该细菌还显著降低内毒素和促炎细胞因子水平，并调节结肠细菌群落和肝脏脂质代谢相关基因的表达。这些结果表明，植物乳杆菌 NCU116 对 NAFLD 的有益作用的可能潜在机制可能包括两条途径，下调脂肪生成和上调脂肪分解和脂肪酸氧化相关基因的表达。
