Moore P M
Wayne State University, School of Medicine, Department of Neurology, Detroit, MI.
J Neurol Sci. 1989 Nov;93(2-3):129-45. doi: 10.1016/0022-510x(89)90184-6.
Vasculitis, or angiitis, affects both the central and peripheral nervous systems and is increasingly recognized as a cause of neurologic dysfunction. The vascular inflammation may be systemic or organ restricted. Recent work has expanded our knowledge on the pathogeneses of vasculitis. Historically, immune complex mediated vasculitis is best defined but studies now delineate cell mediated immune mechanisms including T cell and endothelial cell interactions. Additional factors in the genesis of vascular inflammatory diseases are also being explored. There are numerous underlying etiologies ranging from primary immunologic disturbances to infections, malignancies, and toxins. In order to plan rational therapies, clinicians need to be aware of current work on the pathogeneses of vascular inflammation as well as exploring specific etiologies in their individual patients.
血管炎，又称脉管炎，可累及中枢神经系统和周围神经系统，并且越来越被认为是神经功能障碍的一个病因。血管炎症可能是全身性的，也可能局限于某个器官。最近的研究拓展了我们对血管炎发病机制的认识。从历史上看，免疫复合物介导的血管炎定义最为明确，但现在的研究描绘了细胞介导的免疫机制，包括T细胞与内皮细胞的相互作用。血管炎性疾病发生过程中的其他因素也在探索之中。血管炎有许多潜在病因，从原发性免疫紊乱到感染、恶性肿瘤及毒素等。为了制定合理的治疗方案，临床医生需要了解血管炎症发病机制的当前研究情况，并探究其个体患者的具体病因。
