Korbet S M, Schwartz M M, Lewis E J
Am J Med. 1984 Jul;77(1):141-6. doi: 10.1016/0002-9343(84)90449-2.
Extramural coronary arteries were examined in two patients with systemic lupus erythematosus (SLE). Coronary vasculitis was found in both patients. One patient with clinically and serologically inactive SLE had died suddenly and was found to have a myocardial infarction secondary to the coronary vasculitis. Immunopathologic studies demonstrated immune reactants in the walls of inflamed and noninflamed arterial segments in a pattern consistent with immune complex aggregates. Immunologic injury secondary to immune complex deposition may be responsible for the development of coronary disease in patients with SLE. This has been demonstrated in experimental animals but not in humans. Although this is an uncommon complication of SLE, it represents a cause of sudden death and a potentially treatable lesion in this patient population. Its occurrence may be related to the deposition of immune aggregates in the walls of coronary vessels.
对两名系统性红斑狼疮（SLE）患者的壁外冠状动脉进行了检查。两名患者均发现有冠状动脉血管炎。一名临床和血清学表现为非活动期的SLE患者突然死亡，尸检发现其心肌梗死继发于冠状动脉血管炎。免疫病理学研究显示，在炎症和非炎症动脉节段的血管壁中存在免疫反应物，其模式与免疫复合物聚集体一致。免疫复合物沉积继发的免疫损伤可能是SLE患者冠状动脉疾病发生的原因。这一点在实验动物中已得到证实，但在人类中尚未得到证实。虽然这是SLE的一种罕见并发症，但它是该患者群体猝死的一个原因，也是一个潜在可治疗的病变。其发生可能与免疫聚集体在冠状动脉血管壁中的沉积有关。
