Silva Paula Gabriel, Jones Anamaria, Araujo Pola Maria Poli, Natour Jamil
Disciplina de Reumatologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Clinics (Sao Paulo). 2014 Sep;69(9):585-8. doi: 10.6061/clinics/2014(09)02.
Systemic sclerosis is a relatively rare connective tissue disorder characterized by severe and progressive fibrosis of the skin. Due to the current lack of available information on this subject, the aim of the present study was to assess light touch sensations in the hands of patients with systemic sclerosis.
We completed a cross-sectional comparative study. Light touch sensations were evaluated in 30 individuals, including 15 patients with systemic sclerosis who exhibited changes in the dermis of their hands without loss of the distal phalanx and 15 subjects who did not exhibit changes in the upper limbs (control group). The groups were age- and sex-matched. Tactile sensory evaluations were performed using the Semmes-Weinstein monofilament test and the two-point discrimination test.
Statistically significant differences were found between groups in the monofilament test. The study group had lower scores across all points of the hand when compared with the control group. Differences were also found when dominant and non-dominant hands were compared (p<0.05). Statistically significant differences were found between groups for a subset of the assessed points in the two-point discrimination test.
The results of a monofilament test showed that tactile sensation, specifically light touch and deep pressure sensations, is altered in the hands of systemic sclerosis patients.
系统性硬化症是一种相对罕见的结缔组织疾病，其特征是皮肤严重且进行性纤维化。由于目前关于该主题的可用信息匮乏，本研究的目的是评估系统性硬化症患者手部的轻触觉。
我们完成了一项横断面比较研究。对30个人进行了轻触觉评估，其中包括15名手部真皮层有变化但未丧失远端指骨的系统性硬化症患者，以及15名上肢未出现变化的受试者（对照组）。两组在年龄和性别上相匹配。使用Semmes-Weinstein单丝试验和两点辨别试验进行触觉感官评估。
在单丝试验中，两组之间存在统计学上的显著差异。与对照组相比，研究组手部所有部位的得分较低。比较优势手和非优势手时也发现了差异（p<0.05）。在两点辨别试验中，两组在部分评估点上存在统计学上的显著差异。
单丝试验结果表明，系统性硬化症患者手部的触觉，特别是轻触觉和深压觉发生了改变。
