Arthritis Rheum. 1980 May;23(5):581-90. doi: 10.1002/art.1780230510.
A multicenter, ongoing study of early-diagnosed cases of systemic sclerosis and comparison patients with systemic lupus erythematosus, polymyositis/dermatomyositis, and Raynaud's phenomenon was conducted in order to develop classification criteria for systemic sclerosis. Preliminary criteria are proposed namely, the finding of either the sole major criterion, i.e., proximal scleroderma, or two or more of the minor criteria, i.e., 1) sclerodactyly, 2) digital pitting scars of fingertips or loss of substance of the distal finger pad, and 3) bilateral basilar pulmonary fibrosis. When applied to the case and comparison patients included in this study, these proposed criteria had a 97% sensitivity for definite systemic sclerosis and 98% specificity.
为制定系统性硬化症的分类标准，开展了一项多中心、正在进行的研究，纳入早期诊断的系统性硬化症病例，并与系统性红斑狼疮、多发性肌炎/皮肌炎及雷诺现象患者进行比较。提出了初步标准，即要么发现唯一的主要标准近端硬皮病，要么发现两条或更多次要标准，即1）指端硬化；2）指尖凹陷性瘢痕或远端指腹组织缺失；3）双侧基底肺纤维化。将这些提议的标准应用于本研究纳入的病例和对照患者时，对于确诊的系统性硬化症，其敏感性为97%，特异性为98%。
