Tatara Raine, Sato Makoto, Fujiwara Shin-ichiro, Oh Iekuni, Muroi Kazuo, Ozawa Keiya, Nagai Tadashi
Division of Hematology, Jichi Medical University, Japan.
Intern Med. 2014;53(20):2365-8. doi: 10.2169/internalmedicine.53.2457. Epub 2014 Oct 15.
Hemophagocytic lymphohistiocytosis (HLH), which is associated with various underlying conditions, is characterized by hypercytokinemia. Because it is frequently lethal, immediate mitigation of the hypercytokinemia is vital to save patients, particularly when treatments for the patient's underlying condition are ineffective on HLH. We herein present a case of Hodgkin lymphoma associated with HLH in which the HLH did not improve even after chemotherapy. We attempted to save the patient using hemoperfusion with a polymyxin B-immobilized fiber column to remove cytokines; following this treatment, the patient rapidly recovered. Hemoperfusion may be a strategic method to rescue intractable HLH patients.
噬血细胞性淋巴组织细胞增生症（HLH）与多种潜在疾病相关，其特征为细胞因子血症。由于它常常致命，迅速缓解细胞因子血症对于挽救患者至关重要，尤其是当针对患者潜在疾病的治疗对HLH无效时。我们在此报告一例与HLH相关的霍奇金淋巴瘤病例，该患者即使在化疗后HLH仍未改善。我们尝试使用多粘菌素B固定纤维柱进行血液灌流以清除细胞因子来挽救患者；经过该治疗后，患者迅速康复。血液灌流可能是挽救难治性HLH患者的一种策略性方法。
