Hagihara Masao, Inoue Morihiro, Hua Jian, Iwaki Yasunobu
Department of Hematology, Eiju General Hospital, Japan.
Intern Med. 2012;51(21):3067-72. doi: 10.2169/internalmedicine.51.8275. Epub 2012 Nov 1.
Hemophagocytic lymphohistocytosis (HLH) is commonly associated with infectious diseases or T/NK cell-lymphoma; however that with Hodgkin lymphoma (HL) was rarely reported. Herein, we describe a young male diagnosed with lymphocyte-depleted HL (LD-HL) complicated by HLH as an initial manifestation. He was given high-dose steroid therapy plus recombinant thrombomodulin, and subsequent ABVd (doxorubicin, bleomycin, vinblastine, dacarbazine) treatment. In spite of the achievement of a partial remission treated with one cycle of ABVd, he relapsed after 3 cycles. To our knowledge, the present case is very rare, and more intensive treatment might be needed for the long-term control of HLH-complicated HL.
噬血细胞性淋巴组织细胞增生症（HLH）通常与感染性疾病或T/NK细胞淋巴瘤相关；然而，与霍奇金淋巴瘤（HL）相关的情况鲜有报道。在此，我们描述了一名年轻男性，其最初表现为诊断为淋巴细胞消减型HL（LD-HL）并伴有HLH。他接受了大剂量类固醇治疗加重组血栓调节蛋白治疗，随后接受ABVd（阿霉素、博来霉素、长春花碱、达卡巴嗪）治疗。尽管经过一个周期的ABVd治疗实现了部分缓解，但他在3个周期后复发。据我们所知，本病例非常罕见，可能需要更强化的治疗来长期控制HLH合并HL。
