Cebesoy O, Isik M, Erzincan T, Pamukcu U, Bilgin F, Subasi M
Bratisl Lek Listy. 2014;115(9):550-3. doi: 10.4149/bll_2014_106.
Heparin and low molecular weight heparin are the most frequently used antithromboembolic drugs in fractures.
We aimed to compare the effects of heparin and enoxaparin, which are used as standard treatment, on viability in degloving injuries.
Thirty rats were used in the study. Three groups were composed including 10 rats in each group. Degloving injuries were formed in the tails of the rats. Enoxaparin was injected subcutaneously to the rats in group 1. Standard heparin was injected subcutaneously to the rats in group 2. Serum physiologic solution was injected subcutaneously to the rats in group 3. The experiment was ended on day 15. The tails of the rats were evaluated clinically and histopathologically.
There was a statistically significant difference in the clinical results (p < 0.05). There was a statistically significant difference in the histopathological results (p < 0.05).
We encountered positive effects of both heparin and enoxaparin on the treatment of degloving injuries in this experimental study. However, the findings of this study should be supported and improved by new experimental and especially clinical studies (Fig. 3, Ref. 18).
肝素和低分子量肝素是骨折治疗中最常用的抗血栓栓塞药物。
我们旨在比较作为标准治疗药物的肝素和依诺肝素对脱套伤组织存活能力的影响。
本研究使用30只大鼠。将其分为三组，每组10只。在大鼠尾部造成脱套伤。对第1组大鼠皮下注射依诺肝素。对第2组大鼠皮下注射标准肝素。对第3组大鼠皮下注射血清生理溶液。实验在第15天结束。对大鼠尾部进行临床和组织病理学评估。
临床结果存在统计学显著差异（p < 0.05）。组织病理学结果存在统计学显著差异（p < 0.05）。
在本实验研究中，我们发现肝素和依诺肝素对脱套伤治疗均有积极作用。然而，本研究结果应通过新的实验研究，尤其是临床研究予以支持和完善（图3，参考文献18）。
