Kim Minjeong, Seo Sangwook, Sung Kyunghwa, Kim Kisok
College of Pharmacy, Keimyung University, Daegu, 704-701, Republic of Korea.
Biol Trace Elem Res. 2014 Dec;162(1-3):175-80. doi: 10.1007/s12011-014-0145-y. Epub 2014 Oct 16.
Although exposure to arsenic (As) induces neurotoxic changes, there is a lack of data regarding its specific effects on neurotransmission, particularly dopaminergic neurotransmission. In this study, the dopamine content and expression of tyrosine hydroxylase (TH) and dopamine receptors (DRs) were examined in the striatum and cerebral cortex of the mouse brain following the administration of As (1-100 mg/L NaAsO2 in drinking water). After 3 weeks, significantly decreased TH expression and dopamine content, both in the striatum and the cerebral cortex of mice treated with 100 mg/L As, were observed when compared with controls. Although DR expression was similar in the cerebral cortex of As-treated mice, DRD1 to DRD4 expression significantly increased in the striatum of 100 mg/L As-exposed mice. These data indicate that altered dopaminergic neurotransmission may contribute to As-induced neurotoxic effects.
尽管接触砷（As）会引发神经毒性变化，但关于其对神经传递，特别是多巴胺能神经传递的具体影响的数据却很缺乏。在本研究中，给小鼠饮用含砷（1-100 mg/L 亚砷酸钠）的水后，检测了小鼠脑纹状体和大脑皮层中多巴胺含量、酪氨酸羟化酶（TH）及多巴胺受体（DRs）的表达。3周后，与对照组相比，观察到饮用100 mg/L砷的小鼠纹状体和大脑皮层中TH表达及多巴胺含量均显著降低。虽然砷处理小鼠大脑皮层中的DR表达相似，但在饮用100 mg/L砷的小鼠纹状体中，DRD1至DRD4的表达显著增加。这些数据表明，多巴胺能神经传递的改变可能是砷诱导神经毒性作用的原因之一。
