Dewit L, Oussoren Y, Bartelink H, Thames H D
Department of Experimental Radiotherapy, Antoni van Leeuwenhoekhuis, Amsterdam, The Netherlands.
Radiother Oncol. 1989 Oct;16(2):121-8. doi: 10.1016/0167-8140(89)90029-7.
The influence of cis-diamminedichloroplatinum(II) (c-DDP) on radiation injury in the rectum of mice was investigated after single dose and fractionated irradiation. Mice were exposed to single doses, or 2, 4 or 8 fractions of X-rays given daily (or twice a day for the 8 fractions) with or without 8 mg/kg of c-DDP. The incidence of rectal stenosis and of anal discharge were scored and a direct analysis of the data for linear-quadratic dose-dependence of damage was performed with correction for censoring. For each endpoint, c-DDP did not significantly change the dose-response curves after fractionated irradiation. Subtile modifications in the coefficients of the linear-quadratic relationship were observed. The drug appeared to increase the alpha term by a factor of 2.3 and the beta term by a factor of 1.5, but the differences did not reach statistical significance. For the rectal stenosis endpoint, the alpha/beta was 4.4 Gy after irradiation alone and 6.9 Gy after combination treatment. Again the differences were not significant. These data suggest that c-DDP did not reduce the repair capacity in the mouse rectum during fractionated irradiation. Combined modality therapy with c-DDP and radiation would therefore not be expected to cause an increase in late damage in the large bowel.
研究了顺二氯二氨铂（II）（c-DDP）在单次剂量和分次照射后对小鼠直肠辐射损伤的影响。将小鼠暴露于单次剂量，或每天给予2、4或8次X射线分次照射（8次分次照射时每天两次），同时或不同时给予8mg/kg的c-DDP。对直肠狭窄和肛门分泌物的发生率进行评分，并对数据进行直接分析，以校正删失数据后进行损伤的线性二次剂量依赖性分析。对于每个终点，c-DDP在分次照射后并未显著改变剂量反应曲线。观察到线性二次关系系数有细微变化。该药物似乎使α项增加了2.3倍，β项增加了1.5倍，但差异未达到统计学显著性。对于直肠狭窄终点，单独照射后α/β为4.4Gy，联合治疗后为6.9Gy。差异同样不显著。这些数据表明，c-DDP在分次照射期间并未降低小鼠直肠的修复能力。因此，c-DDP与放疗的联合模式疗法预计不会导致大肠晚期损伤增加。
