Landuyt W, Ang K K, van der Schueren E
Br J Cancer. 1986 Oct;54(4):579-86. doi: 10.1038/bjc.1986.212.
Tolerance of the lip mucosa of NMRI mice to single and fractionated irradiation combined with cis-diamminedichloroplatinum (II) (cis-DDP) was investigated. For the various combination schedules total drug doses varying from 6 mg kg-1 to 13 mg kg-1 were injected i.p. It was found that cis-DDP did not alter the radiation sensitivity of this tissue at any of the time intervals tested (ranging from 24 h before to 72 h after single dose irradiations). When 5 daily drug injections were given concomitantly with 5 daily radiation treatments, a slight reduction of the lip mucosal reactions occurred, possibly due to partial synchronisation during treatment. No effect was seen when a single injection of cis-DDP preceded two irradiations given with increasing intervals up to 4 h. Both these combined fractionated treatment data suggest no inhibitory effect on repair of sublethal radiation damage. When repeated daily injections of cis-DDP were given in between 2 radiation doses separated by 10 days, no interference with repopulation could be detected. The present study also demonstrated an increase in systemic drug toxicity when cis-DDP was combined with irradiation, compared with that seen with either agent alone.
研究了NMRI小鼠唇黏膜对单次和分次照射联合顺二氯二氨铂（II）（顺铂）的耐受性。对于各种联合方案，腹腔注射的总药物剂量为6mg/kg至13mg/kg。发现在任何测试的时间间隔（从单次剂量照射前24小时到照射后72小时），顺铂均未改变该组织的辐射敏感性。当每日注射5次药物与每日5次放射治疗同时进行时，唇黏膜反应略有减轻，这可能是由于治疗期间的部分同步化所致。当在两次照射前单次注射顺铂，照射间隔逐渐增加至4小时时，未观察到任何影响。这两个联合分次治疗数据均表明对亚致死性辐射损伤的修复没有抑制作用。当在间隔10天的两次放射剂量之间每日重复注射顺铂时，未检测到对再增殖的干扰。本研究还表明，与单独使用任何一种药物相比，顺铂与照射联合使用时全身药物毒性增加。
