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利用通过可变形配准获得的对比增强4D CT图像定义肝细胞癌内部肿瘤总体积的可行性及潜在益处。

Feasibility and potential benefits of defining the internal gross tumor volume of hepatocellular carcinoma using contrast-enhanced 4D CT images obtained by deformable registration.

作者信息

Xu Hua, Gong Guanzhong, Wei Hong, Chen Lusheng, Chen Jinhu, Lu Jie, Liu Tonghai, Zhu Jian, Yin Yong

机构信息

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Laboratory of Radiation Oncology, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, China.

出版信息

Radiat Oncol. 2014 Oct 16;9:221. doi: 10.1186/s13014-014-0221-7.

DOI:10.1186/s13014-014-0221-7
PMID:25319176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4205285/
Abstract

OBJECTIVE

To study the feasibility and the potential benefits of defining the internal gross tumor volume (IGTV) of hepatocellular carcinoma (HCC) using contrast-enhanced 4D CT images obtained by combining arterial-phase (AP) contrast-enhanced (CE) 3D CT and non-contrast-enhanced (NCE) 4D CT images using deformable registration (DR).

METHODS

Ten HCC patients who had received radiotherapy beforehand were selected for this study. The following CT simulation images were acquired sequentially: NCE 4D CT in free breathing, NCE 3D CT and APCE 3D CT in end-expiration breath holding. All 4D CT images were sorted into ten phases according to breath cycle (CT00 ~ CT90). Gross tumor volumes (GTVs) were contoured on all CT images and the IGTV-1 was obtained by merging the GTVs in each phase of 4D CT images. The GTV on the APCE 3D CT image was deformably registered to each 4D CT phase image according to liver shape using RayStation(TM) 3.99.0.7 version treatment planning system. The IGTV-DR was obtained by merging the GTVs after DR on the 4D CT images. Volume differences among the GTVs and between the IGTV-1 and the IGTV-DR were compared.

RESULTS

The edge of most lesions could be definitively identified using APCE 3D CT images compared to NCE 4D and 3D CT images. The GTV volume on APCE 3D CT images increased by an average of 34.79% (P<0.05). There was no significant difference among the GTV volumes obtained using NCE 4D and 3D CT images (P>0.05). The GTV volumes after DR on 4D CT different phase images increased by an average of 36.29% (P<0.05), as was observed using the APCE 3D CT image (P>0.05). Lastly, the volume of IGTV-DR increased by an average of 19.91% compared to that of IGTV-1 (P<0.05).

CONCLUSION

NCE 4D CT imaging alone has the potential risk of missing a partial volume of the HCC. The combination of APCE 3D CT and NCE 4D CT images using the DR technique improved the accuracy of the definition of the IGTV in HCC.

摘要

目的

研究通过将动脉期（AP）对比增强（CE）三维CT与非对比增强（NCE）四维CT图像经可变形配准（DR）相结合获得的对比增强四维CT图像来定义肝细胞癌（HCC）的内部大体肿瘤体积（IGTV）的可行性及潜在益处。

方法

选取10例曾接受过放疗的HCC患者进行本研究。依次采集以下CT模拟图像：自由呼吸状态下的NCE四维CT、呼气末屏气状态下的NCE三维CT和APCE三维CT。所有四维CT图像根据呼吸周期分为十个时相（CT00~CT90）。在所有CT图像上勾勒出大体肿瘤体积（GTV），并通过合并四维CT图像各时相的GTV得到IGTV-1。使用RayStation(TM) 3.99.0.7版本治疗计划系统，根据肝脏形状将APCE三维CT图像上的GTV与四维CT各时相图像进行可变形配准。通过合并四维CT图像上经配准后的GTV得到IGTV-DR。比较GTV之间以及IGTV-1与IGTV-DR之间的体积差异。

结果

与NCE四维CT和三维CT图像相比，多数病灶的边缘在APCE三维CT图像上能更明确地显示。APCE三维CT图像上的GTV体积平均增加34.79%（P<0.05）。使用NCE四维CT和三维CT图像获得的GTV体积之间无显著差异（P>0.05）。四维CT不同时相图像经配准后的GTV体积平均增加36.29%（P<0.05），与APCE三维CT图像的情况相似（P>0.05）。最后，与IGTV-1相比，IGTV-DR的体积平均增加19.91%（P<0.05）。

结论

单纯的NCE四维CT成像存在遗漏部分HCC体积的潜在风险。采用DR技术将APCE三维CT与NCE四维CT图像相结合可提高HCC中IGTV定义的准确性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/030a43baee26/13014_2014_221_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/e629b2c51398/13014_2014_221_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/a4bd4bb4ba81/13014_2014_221_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/443da9e8c692/13014_2014_221_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/030a43baee26/13014_2014_221_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/e629b2c51398/13014_2014_221_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/a4bd4bb4ba81/13014_2014_221_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/443da9e8c692/13014_2014_221_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca20/4205285/030a43baee26/13014_2014_221_Fig4_HTML.jpg

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本文引用的文献

1
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Radiat Oncol. 2014 Jan 9;9:11. doi: 10.1186/1748-717X-9-11.
2
Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response.采用扫描碳离子束进行分次碳离子治疗肝癌患者的可行性和临床疗效。
Radiat Oncol. 2013 Mar 13;8:59. doi: 10.1186/1748-717X-8-59.
3
Four-dimensional dose evaluation using deformable image registration in radiotherapy for liver cancer.
通过优化投影 binning 减少低螺距螺旋 4D CT 中与呼吸不规则相关的运动伪影。
Radiat Oncol. 2017 Jun 19;12(1):100. doi: 10.1186/s13014-017-0835-7.
4
Magnitude and influencing factors of respiration-induced liver motion during abdominal compression in patients with intrahepatic tumors.肝内肿瘤患者腹部加压时呼吸诱导的肝脏运动的幅度及影响因素
Radiat Oncol. 2017 Jan 10;12(1):9. doi: 10.1186/s13014-016-0762-z.
5
Interobserver variability in gross tumor volume delineation for hepatocellular carcinoma : Results of Korean Radiation Oncology Group 1207 study.肝细胞癌大体肿瘤体积勾画的观察者间变异性：韩国放射肿瘤学组1207研究结果
Strahlenther Onkol. 2016 Oct;192(10):714-21. doi: 10.1007/s00066-016-1028-2. Epub 2016 Aug 18.
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Med Phys. 2013 Jan;40(1):011706. doi: 10.1118/1.4769427.
4
Advances in 4D radiation therapy for managing respiration: part I - 4D imaging.在管理呼吸的 4D 放射治疗方面的进展：第一部分 - 4D 成像。
Z Med Phys. 2012 Dec;22(4):258-71. doi: 10.1016/j.zemedi.2012.06.009. Epub 2012 Jul 10.
5
Four dimensional CT imaging: a review of current technologies and modalities.四维CT成像：当前技术与模式综述
Australas Phys Eng Sci Med. 2012 Mar;35(1):9-23. doi: 10.1007/s13246-012-0124-6.
6
Use of combined maximum and minimum intensity projections to determine internal target volume in 4-dimensional CT scans for hepatic malignancies.使用最大和最小强度投影的组合来确定肝恶性肿瘤的 4DCT 扫描中的内部靶区。
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7
A four-dimensional computed tomography analysis of multiorgan abdominal motion.多器官腹部运动的四维计算机断层分析。
Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):435-41. doi: 10.1016/j.ijrobp.2011.06.1970. Epub 2011 Dec 22.
8
Improving target delineation on 4-dimensional CT scans in stage I NSCLC using a deformable registration tool.利用形变配准工具改善 I 期非小细胞肺癌 4 维 CT 扫描中的靶区勾画。
Radiother Oncol. 2010 Jul;96(1):67-72. doi: 10.1016/j.radonc.2010.05.003.
9
Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors?几何不确定性的生物学影响：肝内肿瘤需要多大的边缘？
Radiat Oncol. 2010 Jun 3;5:48. doi: 10.1186/1748-717X-5-48.
10
Four-dimensional dosimetry validation and study in lung radiotherapy using deformable image registration and Monte Carlo techniques.基于形变图像配准和蒙特卡罗技术的肺部放射治疗四维剂量学验证和研究。
Radiat Oncol. 2010 May 29;5:45. doi: 10.1186/1748-717X-5-45.