Ruiz Marina, Mulero Patricia, Pedraza María Isabel, de la Cruz Carolina, Rodríguez Cristina, Muñoz Irene, Barón Johanna, Guerrero Angel Luis
Neurology Department, Hospital Clínico Universitario, Valladolid, Spain.
Headache. 2015 Jan;55(1):167-73. doi: 10.1111/head.12460. Epub 2014 Oct 16.
OBJECTIVES/BACKGROUND: We analyzed characteristics of hypnic headache (HH), migraine and the relationship between both headaches in 23 patients. HH is an uncommon primary headache characterized by exclusively sleep-related attacks. Concurrence of other headaches, mainly migraine, has been reported, but relationship between both syndromes has rarely been considered.
We prospectively collected data in a headache outpatient office from January 2008 to September 2013. Demographic data and migraine and hypnic headache mean features were assessed.
Twenty-three out of 2500 (0.92%) were diagnosed with HH or probable HH, and 16 of them (69.5%) had a history of migraine. Mean age at onset of HH and migraine was 56.2 ± 9.3 and 24.6 ± 12.2 years, respectively. In 12 cases, migraine attacks disappeared at 56.7 ± 9.8 years old. Regarding the relationship between both syndromes, in 10 patients, migraine disappeared and HH began immediately after. In 1 case there was a pain-free period, and in 5 an overlap between both headaches was registered.
A history of migraine is common in HH patients in our series. Most frequent transition pattern was an immediate change between both syndromes. Hypnic headache and migraine might share a common pathophysiological predisposition.
目的/背景：我们分析了23例患者的睡眠性头痛（HH）、偏头痛的特征以及两种头痛之间的关系。HH是一种罕见的原发性头痛，其特征为仅在睡眠相关发作时出现。已有报道其他头痛（主要是偏头痛）与HH并存，但两种综合征之间的关系很少被探讨。
我们于2008年1月至2013年9月在头痛门诊前瞻性收集数据。评估人口统计学数据以及偏头痛和睡眠性头痛的平均特征。
2500例患者中有23例（0.92%）被诊断为HH或疑似HH，其中16例（69.5%）有偏头痛病史。HH和偏头痛的平均发病年龄分别为56.2±9.3岁和24.6±12.2岁。在12例患者中，偏头痛发作在56.7±9.8岁时消失。关于两种综合征之间的关系，10例患者偏头痛消失后HH立即发作。1例有疼痛缓解期，5例两种头痛有重叠。
在我们的系列研究中，偏头痛病史在HH患者中很常见。最常见的转变模式是两种综合征之间的立即转变情况。睡眠性头痛和偏头痛可能有共同的病理生理易感性。
