Lemarié Jérémie, Barraud Damien, Gibot Sébastien
Department of Medical Intensive Care, Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France.
Methods Mol Biol. 2015;1237:225-39. doi: 10.1007/978-1-4939-1776-1_17.
The diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. TREM-1, the triggering receptor expressed on myeloid cells-1, is an amplifier of the innate immune response. Its soluble form acts as a decoy for the natural TREM-1 ligand and dampens its activation. In this chapter, we review the numerous studies that have evaluated the usefulness of sTREM-1 concentration determination for the diagnosis and the prognosis evaluation of sepsis or localized infection. Nowadays, sandwich ELISA kits are available and the assay is described.
脓毒症的诊断，尤其是其与无菌性炎症的鉴别诊断，可能具有挑战性。髓系细胞触发受体-1（TREM-1）是先天免疫反应的放大器。其可溶性形式可作为天然TREM-1配体的诱饵并抑制其激活。在本章中，我们回顾了众多评估可溶性TREM-1浓度测定对脓毒症或局部感染的诊断及预后评估价值的研究。如今，夹心酶联免疫吸附测定试剂盒已有供应，且该检测方法也有相关描述。
