脓毒症中的宿主反应生物标志物：可溶性髓系细胞触发受体-1检测概述
Host response biomarkers in sepsis: overview on sTREM-1 detection.
作者信息
Lemarié Jérémie, Barraud Damien, Gibot Sébastien
机构信息
Department of Medical Intensive Care, Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France.
出版信息
Methods Mol Biol. 2015;1237:225-39. doi: 10.1007/978-1-4939-1776-1_17.
The diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. TREM-1, the triggering receptor expressed on myeloid cells-1, is an amplifier of the innate immune response. Its soluble form acts as a decoy for the natural TREM-1 ligand and dampens its activation. In this chapter, we review the numerous studies that have evaluated the usefulness of sTREM-1 concentration determination for the diagnosis and the prognosis evaluation of sepsis or localized infection. Nowadays, sandwich ELISA kits are available and the assay is described.
脓毒症的诊断，尤其是其与无菌性炎症的鉴别诊断，可能具有挑战性。髓系细胞触发受体-1（TREM-1）是先天免疫反应的放大器。其可溶性形式可作为天然TREM-1配体的诱饵并抑制其激活。在本章中，我们回顾了众多评估可溶性TREM-1浓度测定对脓毒症或局部感染的诊断及预后评估价值的研究。如今，夹心酶联免疫吸附测定试剂盒已有供应，且该检测方法也有相关描述。
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