马拉维轮状病毒是一种流行的人类病毒，与已知的肿瘤抑制因子相互作用。
Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.
机构信息
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA.
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
出版信息
J Virol. 2015 Jan;89(1):857-62. doi: 10.1128/JVI.02328-14. Epub 2014 Oct 15.
Abstract
Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.
摘要
马拉维多瘤病毒（MWPyV）是一种最近被发现的人类多瘤病毒。针对 MWPyV VP1 的血清学检测表明，该病毒感染在儿童中很常见，在成年人中的流行率达到 75%。MWPyV 的小 T 抗原（ST）结合蛋白磷酸酶 2A（PP2A），而大 T 抗原（LT）结合 pRb、p107、p130 和 p53。然而，MWPyV LT 不如猿猴病毒 40（SV40）LT 稳定，并且无法促进正常细胞的生长。本报告证实 MWPyV 是一种广泛存在的人类病毒，表达具有低转化潜能的 T 抗原。
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