猪干扰素诱导跨膜蛋白能有效抑制甲型流感病毒复制。
Swine interferon-inducible transmembrane proteins potently inhibit influenza A virus replication.
机构信息
Institute of Medical Virology, University of Zurich, Zurich, Switzerland Life Sciences Zurich Graduate School, ETH and University of Zurich, Zurich, Switzerland.
Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
出版信息
J Virol. 2015 Jan;89(1):863-9. doi: 10.1128/JVI.02516-14. Epub 2014 Oct 15.
Abstract
Human interferon-inducible transmembrane proteins (IFITMs) were identified as restriction factors of influenza A virus (IAV). Given the important role of pigs in the zoonotic cycle of IAV, we cloned swine IFITMs (swIFITMs) and found two IFITM1-like proteins, one homologue of IFITM2, and a homologue of IFITM3. We show that swIFITM2 and swIFITM3 localize to endosomes and display potent antiviral activities. Knockdown of swIFITMs strongly reduced virus inhibition by interferon, establishing the swIFITMs as potent restriction factors in porcine cells.
摘要
人类干扰素诱导跨膜蛋白（IFITMs）被鉴定为流感 A 病毒（IAV）的限制因子。鉴于猪在 IAV 的人畜共患病循环中的重要作用，我们克隆了猪 IFITMs（swIFITMs），并发现了两种 IFITM1 样蛋白、一种 IFITM2 同源物和一种 IFITM3 同源物。我们表明 swIFITM2 和 swIFITM3 定位于内体，并显示出强大的抗病毒活性。swIFITMs 的敲低强烈降低了干扰素对病毒的抑制作用，证明 swIFITMs 是猪细胞中强大的限制因子。
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本文引用的文献
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Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses.猪干扰素诱导跨膜基因家族的进化特征及感染猪呼吸道疾病病毒的猪气管支气管淋巴结中成员的表达动态
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