尼日利亚镰状细胞病患者的中风患病率：一项多中心研究。
Stroke prevalence amongst sickle cell disease patients in Nigeria: a multi-centre study.
作者信息
Jude Madu Anazoeze, Aliyu Galadanci Najiba, Nalado Aisha Mohammed, Garba Kangiwa Umar, Florence Fowodu O, Hassan Ahmed, Inyama Marcus, Akinpelu Oluwaseun, Theresa Nwagha, Godswill Ibegbulam Obike, Sunday Ocheni, Ifeoma Emodi, Anthony Ikefuna, Batholomew Chukwu, Chide Okocha E, Joseph Orkuma, Malachy Iheanacho, Korubo Kaladada, Sabastine Anike Uchenna, Kingsley Agu, Nonyelu Charles, Ugwu Angela, Duru Augustin, Anigbo Chukwudi, Eze Alozie, Chukwurah Awele, Ololo Uchenna, Omoti Caroline, Agwu Obineche, Iheanyi Okpala
机构信息
Department of Haematology & Immunology, University of Nigeria Enugu Campus (UNEC), Enugu.
Department of Haematology, Aminu Kano Teaching Hospital, Kano.
出版信息
Afr Health Sci. 2014 Jun;14(2):446-52. doi: 10.4314/ahs.v14i2.22.
BACKGROUND
Stroke is a life-changing, debilitating complication of sickle cell disease (SCD). Previous studies had recorded high stroke prevalence amongst this group of patients. Nigeria has a large population of people affected by this condition and this study aims to assess the stroke prevalence in this large population.
METHODOLOGY
Stroke prevalence data from 14 physicians working in 11 tertiary health centres across the country was collated by doctors using the sickle cell registers and patient case notes. This data was then collated and used to obtain the overall stroke prevalence in adult and children.
RESULTS
The stroke prevalence in sickle cell disease patients in Nigeria was observed to be 12.4 per 1000 patients. Prevalence in the adult patients was 17.7 per 1000 patients and 7.4 per 1000 patients in children. Twenty three percent of the affected patients had more than stroke episode.
CONCLUSION
The stroke prevalence in Nigeria is lower than previously recorded rates and further studies will be required to investigate other factors which may play a role.
背景
中风是镰状细胞病（SCD）一种改变生活、使人衰弱的并发症。此前的研究记录了这类患者中中风的高患病率。尼日利亚有大量受这种疾病影响的人群，本研究旨在评估这一庞大人群中的中风患病率。
方法
医生通过镰状细胞病登记册和患者病历，整理了来自全国11家三级医疗中心的14名医生提供的中风患病率数据。然后对这些数据进行整理，以得出成人和儿童的总体中风患病率。
结果
尼日利亚镰状细胞病患者的中风患病率为每1000名患者中有12.4例。成人患者的患病率为每1000名患者中有17.7例，儿童为每1000名患者中有7.4例。23%的受影响患者有不止一次中风发作。
结论
尼日利亚的中风患病率低于此前记录的比率，需要进一步研究以调查可能起作用的其他因素。
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