Adigwe Obi Peter, Onavbavba Godspower, Onoja Solomon Oloche
National Institute for Pharmaceutical Research and Development, Abuja, Federal Capital Territory, Nigeria.
Department of Medical Laboratory Sciences, University of Nigeria, Enugu, Nigeria.
Int J Gen Med. 2023 Aug 14;16:3503-3515. doi: 10.2147/IJGM.S410015. eCollection 2023.
Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as the country with the highest burden of sickle cell disease globally. This study aimed at critically reviewing available literature on impact of sickle cell disease in Nigeria. A literature search was carried out on four databases, and a total of 116 articles that met the inclusion criteria were included in the critical review. It was observed that majority of the studies were carried out in South-Western part of Nigeria (47.4%), whilst the North-East had the least number of studies undertaken in this area, more than a quarter of the studies (27.6%) were related to hematologic and serologic screening. Major themes that emerged from this review were morbidity and mortality; prevalence of sickle cell disease; issues relating to blood transfusion; psychosocial impact; and anatomical dysfunction in sickle cell disease. Intervention programs from both government and non-governmental organizations aimed at reducing the burden of sickle cell disease and its socio-economic impact were identified as key to strategies aimed at overcoming challenges associated with the disease. Findings from this study also revealed that education and awareness interventions were central to reducing the prevalence of sickle cell disease in this setting.
镰状细胞病是一种β-珠蛋白基因的常染色体隐性疾病，会导致红细胞变形以及临床结果各异。尼日利亚被认为是全球镰状细胞病负担最重的国家。本研究旨在严格审查有关镰状细胞病在尼日利亚影响的现有文献。在四个数据库中进行了文献检索，共有116篇符合纳入标准的文章被纳入此次严格审查。研究发现，大多数研究在尼日利亚西南部开展（47.4%），而东北部在该领域开展的研究数量最少，超过四分之一的研究（27.6%）与血液学和血清学筛查有关。此次审查中出现的主要主题包括发病率和死亡率；镰状细胞病的患病率；与输血相关的问题；心理社会影响；以及镰状细胞病中的解剖功能障碍。政府和非政府组织旨在减轻镰状细胞病负担及其社会经济影响的干预项目被确定为克服与该疾病相关挑战的战略关键。本研究的结果还表明，教育和提高认识的干预措施对于降低该地区镰状细胞病的患病率至关重要。
