Ostovan Mohammadali, Aslani Amir, Abounajmi Shahima, Razazi Vida
Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
School of Management and Information, Shiraz University of Medical Sciences, Shiraz, Iran.
J Cardiovasc Thorac Res. 2014;6(3):191-5. doi: 10.15171/jcvtr.2014.010. Epub 2014 Sep 30.
High sensitive C-Reactive Protein (hs-CRP) is increased in acute and chronic rheumatic fever (RF), but is unknown whether serum levels of hs-CRP is correlated with late restenosis of mitral valve (MV) after Percutaneous transvenous mitral commissurotomy (PTMC). The aim of this study is to determine relationship between hs-CRP and MV restenosis 48-36 months after performing PTMC.
A total of 50 patients who had undergone PTMC due to rheumatic etiology (41 female, 9 male; mean age 46 ± 11, range 27-71), all followed up on an out patients basis 36 months after PTMC, were included in the study. The hs-CRP was measured using an enzyme-linked immunosorbent assay (ELISA) kits.
No association was found between hs-CRP level and mean transmitral valve gradient 36 months after PTMC, MV area by planimetry, pulmonary artery systolic pressure, mitral regurgitation grade, left atrial diameter, atrial fibrillation (AF) rhythm and Wilkins score.
Our study have shown that there is no association between hs-CRP and MV restenosis in patients with rheumatic heart disease (RHD) who underwent PTMC. Therefore, it has been postulated that inflammation is not a cause of post PTMC restenosis.
高敏C反应蛋白（hs-CRP）在急性和慢性风湿热（RF）中升高，但经皮经静脉二尖瓣交界切开术（PTMC）后血清hs-CRP水平是否与二尖瓣（MV）晚期再狭窄相关尚不清楚。本研究的目的是确定PTMC术后48 - 36个月hs-CRP与MV再狭窄之间的关系。
本研究纳入了50例因风湿病因接受PTMC的患者（41例女性，9例男性；平均年龄46±11岁，范围27 - 71岁），所有患者在PTMC术后36个月进行门诊随访。使用酶联免疫吸附测定（ELISA）试剂盒测量hs-CRP。
在PTMC术后36个月，未发现hs-CRP水平与平均二尖瓣跨瓣压差、平面测量的MV面积、肺动脉收缩压、二尖瓣反流分级、左心房直径、房颤（AF）心律及威尔金斯评分之间存在关联。
我们的研究表明，接受PTMC的风湿性心脏病（RHD）患者中，hs-CRP与MV再狭窄之间无关联。因此，据推测炎症不是PTMC术后再狭窄的原因。
