*Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya †Department of Clinical Laboratory, Nagano Prefectural Suzaka Hospital, Nagano ‡Department of Pathology ∥Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development **Department of Pathology, Tokai University School of Medicine, Tokyo §Japanese Pediatric Leukemia/Lymphoma Study Group ¶Department of Pediatrics, Aichi Medical University ‡‡Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Aichi #Department of Medical Oncology, Teine Keijinkai Hospital, Hokkaido Prefecture ††Department of Pathology, School of Medicine, Kurume University, Fukuoka, Japan.
Am J Surg Pathol. 2015 Feb;39(2):227-35. doi: 10.1097/PAS.0000000000000332.
Epstein-Barr virus (EBV) is detected in 20% to 30% of sporadic Burkitt lymphoma (sBL). However, only a few studies of EBV-positive (EBV) sBL have been reported, and its characteristics still remain controversial. To highlight the features of EBV sBL, we compared the clinicopathologic characteristics of 33 cases of EBV and 117 cases of EBV-negative (EBV) sBL in Japan. EBV sBL showed significantly higher age distribution (median, 42 vs. 13 y; P<0.0001) and higher frequency of patients older than 50 years (48% vs. 16%, P<0.0001). We also revealed the difference of the involved sites. The EBV group showed significantly higher incidence of involvement of tonsil (P=0.027), adrenal gland (P=0.011), and cervical lymph node (P=0.040). In addition, the EBV group tended to have higher incidence of nodal involvement (P=0.078) and involvement of para-aorta lymph node (P=0.084) and heart (P=0.050). In contrast, the gastrointestinal tract was less frequently affected in EBV sBL (P=0.024). In addition, the less positivity for MUM1 (P=0.020) of EBV sBL was highlighted. These results indicate that biological behavior and pathogenesis of EBV sBL might be different from those of EBV sBL. Our results demonstrate that EBV sBL has an aspect of age-related disease and is a distinct clinicopathologic subtype, which should be distinguished from EBV sBL.
EB 病毒（EBV）在 20%至 30%的散发性伯基特淋巴瘤（sBL）中被检测到。然而，仅有少数 EBV 阳性（EBV）sBL 的研究报告，其特征仍存在争议。为了突出 EBV sBL 的特征，我们比较了日本 33 例 EBV 和 117 例 EBV 阴性（EBV）sBL 的临床病理特征。EBV sBL 的年龄分布明显较高（中位数，42 岁比 13 岁；P<0.0001），50 岁以上患者的频率明显较高（48%比 16%；P<0.0001）。我们还揭示了受累部位的差异。EBV 组扁桃体受累的发生率明显较高（P=0.027），肾上腺（P=0.011）和颈淋巴结（P=0.040）。此外，EBV 组淋巴结受累（P=0.078）和主动脉旁淋巴结（P=0.084）和心脏受累（P=0.050）的发生率也较高。相反，EBV sBL 胃肠道受累较少（P=0.024）。此外，EBV sBL 的 MUM1 阳性率较低（P=0.020）。这些结果表明 EBV sBL 的生物学行为和发病机制可能与 EBV sBL 不同。我们的结果表明 EBV sBL 具有与年龄相关疾病的特征，是一种独特的临床病理亚型，应与 EBV sBL 相区别。
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