Zhang Ji, Chen Qing, Zhang Shuhua
Department of Hepatobiliary Surgery of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Oncol. 2024 Dec 10;14:1439137. doi: 10.3389/fonc.2024.1439137. eCollection 2024.
Burkitt's lymphoma (BL) is a relatively rare post-transplant lymphoproliferative disorder (PTLD), and there is currently limited research on the occurrence of BL following adult liver transplantation.
We report a 45-year-old male who developed BL that rapidly progressed at seven years after left liver transplantation. The patient eventually abandoned treatment due to severe clinical complications.
BL is a highly invasive B-cell-derived non-Hodgkin lymphoma (NHL), with fast progression and easy involvement of the central nervous system. The current case had sporadic BL with atypical site of onset. After analysis, the investigators considered the possible development of tumor lysis syndrome (TLS) in the later stage of hospitalization, which is a more serious complication of BL. There is currently no unified treatment plan for adult BL.
BL is a relatively rare complication after liver transplantation, and its early detection and treatment are crucial. For advanced BL, attention should be given in preventing the occurrence of TLS. Further research and exploration are needed to determine the optimal treatment plan for adult BL.
伯基特淋巴瘤（BL）是一种相对罕见的移植后淋巴增殖性疾病（PTLD），目前关于成人肝移植后发生BL的研究有限。
我们报告一名45岁男性，在左肝移植7年后发生BL且迅速进展。该患者最终因严重的临床并发症而放弃治疗。
BL是一种侵袭性很强的B细胞来源的非霍奇金淋巴瘤（NHL），进展迅速且易累及中枢神经系统。本例为散发性BL且发病部位不典型。经分析，研究者认为患者在住院后期可能发生肿瘤溶解综合征（TLS），这是BL一种较为严重的并发症。目前对于成人BL尚无统一的治疗方案。
BL是肝移植后相对罕见的并发症，早期发现和治疗至关重要。对于晚期BL，应注意预防TLS的发生。需要进一步研究探索以确定成人BL的最佳治疗方案。
