Giagulli V A, Verdonck L, Giorgino R, Vermeulen A
Department of Endocrinology, University Hospital, Ghent, Belgium.
J Steroid Biochem. 1989 Nov;33(5):935-40. doi: 10.1016/0022-4731(89)90243-4.
Although androstanediol (AD) and androstanediolglucuronide (ADG) are generally considered to be parameters of peripheral androgen action, their plasma levels do not always vary in parallel, suggesting that they may have different precursors. Few hard data being available concerning ADG precursors in women, we studied in postmenopausal women with absent or suppressed adrenal function, the blood conversion rates of testosterone (T), dihydrotestosterone (DHT), androstenedione (A) and dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) to AD and ADG respectively, as well as the conversion of AD to ADG. Moreover conversions of these precursors to testosteroneglucuronide (TG) and dihydrotestosteroneglucuronide (DHTG), respectively, were also studied. Our data show that, whereas plasma A and DHT are the major precursors of AD, plasma DHEAS and A are the major precursors of plasma ADG, accounting for 50 and 15%, respectively, of plasma ADG, A being the major precursor of plasma TG and DHTG, respectively. When the conversion rates, obtained in this study, were applied to the plasma concentration of precursors found in normal young and postmenopausal women, respectively, the calculated concentration of product steroids accounted for almost the totality of the actual plasma levels of ADG, TG and DHTG respectively. The difference in relative importance of their precursors, explains that plasma concentrations of AD and ADG do not always vary in parallel; moreover, the importance of DHEAS as precursor of ADG explains the suppression by dexamethasone and the increase after adrenocortical stimulation of plasma ADG levels.
虽然雄烷二醇（AD）和雄烷二醇葡糖苷酸（ADG）通常被认为是外周雄激素作用的参数，但其血浆水平并非总是平行变化，这表明它们可能有不同的前体。关于女性ADG前体的可靠数据很少，我们在肾上腺功能缺失或受抑制的绝经后女性中进行了研究，分别测定了睾酮（T）、双氢睾酮（DHT）、雄烯二酮（A）和脱氢表雄酮（DHEA）及其硫酸盐（DHEAS）转化为AD和ADG的血液转化率，以及AD转化为ADG的转化率。此外，还分别研究了这些前体转化为睾酮葡糖苷酸（TG）和双氢睾酮葡糖苷酸（DHTG）的情况。我们的数据表明，血浆A和DHT是AD的主要前体，而血浆DHEAS和A是血浆ADG的主要前体，分别占血浆ADG的50%和15%，A分别是血浆TG和DHTG的主要前体。当将本研究中获得的转化率分别应用于正常年轻女性和绝经后女性血浆中前体的浓度时，计算得出的产物类固醇浓度分别几乎占ADG、TG和DHTG实际血浆水平的全部。它们前体相对重要性的差异解释了AD和ADG的血浆浓度并非总是平行变化；此外，DHEAS作为ADG前体的重要性解释了地塞米松对血浆ADG水平的抑制作用以及肾上腺皮质刺激后血浆ADG水平的升高。
