Peters Frank T
Bioanalysis. 2014 Aug;6(15):2083-107. doi: 10.4155/bio.14.168.
In the last decade, an ever-increasing number of new psychoactive substances (NPSs) have appeared on the recreational drug market. To account for this development, analytical toxicologists have to continuously adapt their methods to encompass the latest NPSs. Urine is the preferred biological matrix for screening analysis in different areas of analytical toxicology. However, the development of urinalysis procedures for NPSs is complicated by the fact that generally little or no information on urinary excretion patterns of such drugs exists when they first appear on the market. Metabolism studies are therefore a prerequisite in the development of urinalysis methods for NPSs. In this article, the literature on the urinalysis of NPS metabolites will be reviewed, focusing on articles published after 2008.
在过去十年中，越来越多的新型精神活性物质（NPSs）出现在娱乐性毒品市场上。为应对这一发展趋势，分析毒理学家必须不断调整其方法，以涵盖最新的新型精神活性物质。尿液是分析毒理学不同领域筛查分析的首选生物基质。然而，新型精神活性物质尿液分析程序的开发面临着复杂情况，因为当这类药物首次出现在市场上时，关于其尿液排泄模式的信息通常很少或根本不存在。因此，代谢研究是开发新型精神活性物质尿液分析方法的先决条件。在本文中，将对新型精神活性物质代谢物尿液分析的文献进行综述，重点关注2008年以后发表的文章。
