Félix-Martínez Gerardo J, Godínez-Fernández J Rafael
Department of Electrical Engineering; Universidad Autónoma Metropolitana-Iztapalapa ; México , DF , México.
Islets. 2014;6(3):e949195. doi: 10.4161/19382014.2014.949195.
Mathematical modeling of the electrical activity of the pancreatic β-cell has been extremely important for understanding the cellular mechanisms involved in glucose-stimulated insulin secretion. Several models have been proposed over the last 30 y, growing in complexity as experimental evidence of the cellular mechanisms involved has become available. Almost all the models have been developed based on experimental data from rodents. However, given the many important differences between species, models of human β-cells have recently been developed. This review summarizes how modeling of β-cells has evolved, highlighting the proposed physiological mechanisms underlying β-cell electrical activity.
胰腺β细胞电活动的数学模型对于理解葡萄糖刺激胰岛素分泌所涉及的细胞机制极为重要。在过去30年里已经提出了几种模型，随着所涉及细胞机制的实验证据不断出现，这些模型的复杂性也在增加。几乎所有模型都是基于啮齿动物的实验数据开发的。然而，鉴于不同物种之间存在许多重要差异，人类β细胞模型最近也已开发出来。本综述总结了β细胞模型的发展历程，重点介绍了所提出的β细胞电活动潜在生理机制。
