Cui Chaochu, Merritt Robert, Fu Liwu, Pan Zui
State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; Department of Surgery, Division of Thoracic Surgery, The Ohio State University, Columbus, OH 43210, USA.
Department of Surgery, Division of Thoracic Surgery, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Acta Pharm Sin B. 2017 Jan;7(1):3-17. doi: 10.1016/j.apsb.2016.11.001. Epub 2016 Dec 13.
The intracellular calcium ions (Ca) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca channels, transporters and Ca-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca channels/transporters or Ca-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research into the understanding of cellular mechanisms underlying the regulation of Ca signaling in different cancer cells, and to search for novel therapies to cure these malignancies by targeting Ca channels or transporters.
细胞内钙离子（Ca）作为第二信使，调节基因转录、细胞增殖、迁移和死亡。越来越多的证据表明，癌细胞中细胞内Ca稳态发生改变，且这种改变与肿瘤的发生、血管生成、进展和转移有关。针对紊乱的Ca信号进行癌症治疗已成为一个新兴的研究领域。本综述总结了一些重要的Ca通道、转运体和Ca-ATP酶，据报道这些在人类癌症患者中发生了改变。它讨论了目前评估Ca通道/转运体或Ca-ATP酶泵的阻滞剂、抑制剂或调节剂作为抗癌药物的研究工作。本综述还旨在激发人们对理解不同癌细胞中Ca信号调节的细胞机制的研究兴趣并提供支持，并通过靶向Ca通道或转运体寻找治疗这些恶性肿瘤的新疗法。
