Li H, Zhang X, Song Y, Wang T, Tan G
Department of Otolaryngology-Head Neck Surgery,Third Xiangya Hospital, Central South University,Changsha,China.
J Laryngol Otol. 2014 Nov;128(11):976-80. doi: 10.1017/S002221511400228X. Epub 2014 Oct 17.
To evaluate the therapeutic effects of functional endoscopic sinus surgery in patients with chronic rhinosinusitis who were unresponsive to medical treatment.
A total of 232 patients were divided into 2 groups: a functional endoscopic sinus surgery group (n = 162) and a conservative therapy group (n = 70). Efficacy was assessed in terms of Lund-Kennedy endoscopy scores and Sino-Nasal Outcome Test 20 symptom scores.
In the functional endoscopic sinus surgery group, Lund-Kennedy and Sino-Nasal Outcome Test 20 scores were significantly lower at 3, 6 and 12 months post-surgery compared with baseline scores. In the conservative therapy group, both sets of scores were significantly lower at 3 months, but not at 12 months. In this latter group, the Lund-Kennedy scores decreased only slightly and the Sino-Nasal Outcome Test 20 scores significantly decreased at six months compared with initial scores, indicating disparity between the subjective and objective measures. Patient-reported symptom improvement was better in the functional endoscopic sinus surgery group than in the medication group at 12 months (p < 0.001).
These findings suggest that functional endoscopic sinus surgery has better efficacy over a longer period compared with conservative therapy.
评估功能性鼻内镜鼻窦手术对药物治疗无效的慢性鼻-鼻窦炎患者的治疗效果。
总共232例患者被分为两组：功能性鼻内镜鼻窦手术组（n = 162）和保守治疗组（n = 70）。根据Lund-Kennedy内镜评分和鼻窦结局测试20（Sino-Nasal Outcome Test 20）症状评分评估疗效。
在功能性鼻内镜鼻窦手术组中，术后3、6和12个月时的Lund-Kennedy评分和鼻窦结局测试20评分与基线评分相比显著降低。在保守治疗组中，两组评分在3个月时均显著降低，但在12个月时未降低。在该组中，与初始评分相比，Lund-Kennedy评分仅略有下降，而鼻窦结局测试20评分在6个月时显著下降，表明主观和客观测量之间存在差异。在12个月时，功能性鼻内镜鼻窦手术组患者报告的症状改善情况优于药物治疗组（p < 0.001）。
这些发现表明，与保守治疗相比，功能性鼻内镜鼻窦手术在较长时期内具有更好的疗效。
