Guo Rong, Li Yuanmin, Wen Jing, Li Weiming, Xu Yawei
Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Cardiology. 2014;129(3):178-88. doi: 10.1159/000364996. Epub 2014 Oct 10.
This investigation explored the short-term prognostic value of pentraxin-3 (PTX3) levels in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated by percutaneous coronary intervention (PCI).
We measured plasma levels of PTX3 and other biomarkers in 525 PCI-treated NSTEMI patients (mean age, 57.7 years; 328 males). The associations of PTX3 levels with cardiac events and cardiac deaths occurring within 30 days of discharge were evaluated with multivariable Cox proportional hazard models.
Renal function, diabetes prevalence, systolic blood pressure, heart rate and ejection fraction differed significantly in the high PTX3 (≥3.0 ng/ml, n = 107) and low PTX3 (<3.0 ng/ml, n = 418) groups (all p < 0.05). Plasma PTX3 levels were correlated with high-sensitivity C-reactive protein, troponin T and N-terminal pro-B-type natriuretic peptide in NSTEMI patients (all p < 0.05). Kaplan-Meier analysis showed in-hospital and 30-day cardiac events and deaths were higher in the high PTX3 group (both p < 0.01). Elevated PTX3 was an independent predictor of 30-day cardiac events (95% CI 1.09-1.68; p = 0.006) and mortality (95% CI 1.18-2.15; p = 0.002).
An elevated plasma level of PTX3 predicts 30-day cardiac events and mortality in PCI-treated NSTEMI patients.
本研究探讨了经皮冠状动脉介入治疗（PCI）的非ST段抬高型心肌梗死（NSTEMI）患者中，五聚体-3（PTX3）水平的短期预后价值。
我们检测了525例接受PCI治疗的NSTEMI患者（平均年龄57.7岁；男性328例）的血浆PTX3水平及其他生物标志物。采用多变量Cox比例风险模型评估PTX3水平与出院后30天内发生的心脏事件和心源性死亡的相关性。
高PTX3组（≥3.0 ng/ml，n = 107）和低PTX3组（<3.0 ng/ml，n = 418）在肾功能、糖尿病患病率、收缩压、心率和射血分数方面存在显著差异（均p < 0.05）。NSTEMI患者血浆PTX3水平与高敏C反应蛋白、肌钙蛋白T和N末端B型利钠肽原相关（均p < 0.05）。Kaplan-Meier分析显示，高PTX3组的院内及30天心源性事件和死亡发生率更高（均p < 0.01）。PTX3升高是30天心源性事件（95%CI 1.09 - 1.68；p = 0.006）和死亡率（95%CI 1.18 - 2.15；p = 0.002）的独立预测因素。
血浆PTX3水平升高可预测接受PCI治疗的NSTEMI患者30天内心源性事件和死亡率。
