Agozzino Marina, Berardesca Enzo, Donadio Carlo, Franceschini Chiara, de Felice Catia Margarete, Cavallotti Claudia, Sperduti Isabella, Ardigò Marco
San Gallicano Dermatological Institute - IRCCS, Rome, Italy.
Dermatology. 2014;229(3):215-21. doi: 10.1159/000363289. Epub 2014 Oct 15.
Plaque psoriasis (PP) and seborrheic dermatitis (SD) are chronic inflammatory skin diseases with similar clinical and pathological features. Differential diagnosis can be difficult, especially when particular skin areas of the face are involved. Reflectance confocal microscopy (RCM) has been demonstrated to be useful for 'real-time' diagnosis of skin inflammatory diseases.
To define distinctive confocal criteria of SD and to evaluate the usefulness of this technique for noninvasive differential diagnosis with PP.
A total of 40 patients affected by PP and 19 patients by SD involving the face were recruited and subjected to RCM evaluation. Univariate and adjusted odds ratios were calculated. Discriminant functions were used to plot ROC curves.
The results disclosed specific patterns for SD and PP. The following distinctive confocal features for SD have been identified: spongiosis, dermal inflammation and horizontal orientation of dilated blood vessels.
SD has a specific and easily recognizable confocal pattern supporting clinical differentiation with PP.
斑块状银屑病（PP）和脂溢性皮炎（SD）是具有相似临床和病理特征的慢性炎症性皮肤病。鉴别诊断可能具有挑战性，尤其是当面部特定皮肤区域受累时。反射式共聚焦显微镜（RCM）已被证明对皮肤炎症性疾病的“实时”诊断有用。
确定SD的独特共聚焦标准，并评估该技术对PP进行无创鉴别诊断的有用性。
共招募了40例面部受累的PP患者和19例SD患者，并对其进行RCM评估。计算单变量和校正比值比。使用判别函数绘制ROC曲线。
结果揭示了SD和PP的特定模式。已确定SD具有以下独特的共聚焦特征：海绵形成、真皮炎症和扩张血管的水平方向。
SD具有特定且易于识别的共聚焦模式，支持与PP的临床鉴别。
